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Halo-PEG(4)-NH2*HCl

Chemical name: 18-Chloro-3,6,9,12-tetraoxa-octadecan-1-amine hydrochloride // Synonyms: 18-​Chloro-3,​6,​9,​12-​Tetraoxaoctadecan-​1-​amine hydrochloride, net-CAS 1141732-29-7

Product code:RL-3690
CAS No.:1261238-20-3
Formula:C14H30ClNO4*HCl
Molecular weight:311,85*36,46 g/mol
Grouped product items
Qty Packing unit Price SKU
1 g
$1,215.00
RL-3690.1000
5 g
$4,860.00
RL-3690.5000
description

This chloroalkane linker serves as ligand for a specific modified bacterial haloalkane dehalogenase. This is a reporter protein whose sequence can easily be fused to a gene of interest. The reaction between the chloroalkane linker and the enzyme is fast and irreversible under physiological conditions and the system has been used extensively to measure protein-protein interactions in cells.


references

HaloTag technology: a versatile platform for biomedical applications; C. G. England, H. Luo and W. Cai; Bioconjug Chem 2015; 26: 975-86. https://doi.org/10.1021/acs.bioconjchem.5b00191.


HaloTag: a novel protein labeling technology for cell imaging and protein analysis; G. V. Los, L. P. Encell, M. G. McDougall, D. D. Hartzell, N. Karassina, C. Zimprich, M. G. Wood, R. Learish, R. F. Ohana, M. Urh, D. Simpson, J. Mendez, K. Zimmerman, P. Otto, G. Vidugiris, J. Zhu, A. Darzins, D. H. Klaubert, R. F. Bulleit and K. V. Wood; ACS Chem Biol 2008; 3: 373-382. https://doi.org/10.1021/cb800025k.


A MedChem toolbox for cereblon-directed PROTACs; C. Steinebach, I. Sosič, S. Lindner, A. Bricelj, F. Kohl, Y. L. D. Ng, M. Monschke, K. G. Wagner, J. Krönke, M. Gütschow; Med. Chem. Commun. 2019; 10: 1037-1041. https://doi.org/10.1039/C9MD00185A.

Degradation of HaloTag-fused nuclear proteins using bestatin-HaloTag ligand hybrid molecules; S. Tomoshige, M. Naito, Y. Hashimoto, M. Ishikawa; Org. Biomol. Chem. 2015; 13: 9746-9750. https://doi.org/10.1039/C5OB01395J.


Superresolution Imaging of Targeted Proteins in Fixed and Living Cells Using Photoactivatable Organic Fluorophores; H.-I. D. Lee, S. J. Lord, S. Iwanaga, K. Zhan, H. Xie, J. C. Williams, H. Wang, G. R. Bowman, E. D. Goley, L. Shapiro, R. J. Twieg, J. Rao, W. E. Moerner; J. Am. Chem. Soc. 2010; 132(43): 15099-15101. https://doi.org/10.1021/ja1044192.


In Vivo Stable Tumor-Specific Painting in Various Colors Using Dehalogenase-Based Protein-Tag Fluorescent Ligands; N. Kosaka, M. Ogawa, P. L. Choyke, N. Karassina, C. Corona, M. McDougall, D. T. Lynch, C. C. Hoyt, R. M. Levenson, G. V. Los, H. Kobayashi; Bioconjug. Chem. 2009; 20(7): 1367-1374. https://doi.org/10.1021/bc9001344.


Direct pH measurements by using subcellular targeting of 5 (and 6-)carboxyseminaphthorhodafluor in mammalian cells; H. Benink, M. McDougall, D. Klaubert, G. Los; Biotechniques 2009; 47(3): 769-74. https://doi.org/10.2144/000113220. 

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