Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Thank you very much for your interest in our products. All prices listed on our website are ex-works, Germany, and may attract customs duties when imported.
You may/will be contacted by the shipping company for additional documentation that may be required by the US Customs for clearance.
We offer you the convenience of buying though a local partner, Peptide Solutions LLC who can import the shipment as well as prepay the customs duties and brokerage on your behalf and provide the convenience of a domestic sale.Continue to Iris Biotech GmbHSend request to US distributor
Chemical name: 18-Chloro-3,6,9,12-tetraoxa-octadecan-1-amine hydrochloride // Synonyms: 18-Chloro-3,6,9,12-Tetraoxaoctadecan-1-amine hydrochloride, net-CAS 1141732-29-7
|Molecular weight:||311,85*36,46 g/mol|
This chloroalkane linker serves as ligand for a specific modified bacterial haloalkane dehalogenase. This is a reporter protein whose sequence can easily be fused to a gene of interest. The reaction between the chloroalkane linker and the enzyme is fast and irreversible under physiological conditions and the system has been used extensively to measure protein-protein interactions in cells.
HaloTag technology: a versatile platform for biomedical applications; C. G. England, H. Luo and W. Cai; Bioconjug Chem 2015; 26: 975-86. https://doi.org/10.1021/acs.bioconjchem.5b00191.
HaloTag: a novel protein labeling technology for cell imaging and protein analysis; G. V. Los, L. P. Encell, M. G. McDougall, D. D. Hartzell, N. Karassina, C. Zimprich, M. G. Wood, R. Learish, R. F. Ohana, M. Urh, D. Simpson, J. Mendez, K. Zimmerman, P. Otto, G. Vidugiris, J. Zhu, A. Darzins, D. H. Klaubert, R. F. Bulleit and K. V. Wood; ACS Chem Biol 2008; 3: 373-382. https://doi.org/10.1021/cb800025k.
A MedChem toolbox for cereblon-directed PROTACs; C. Steinebach, I. Sosič, S. Lindner, A. Bricelj, F. Kohl, Y. L. D. Ng, M. Monschke, K. G. Wagner, J. Krönke, M. Gütschow; Med. Chem. Commun. 2019; 10: 1037-1041. https://doi.org/10.1039/C9MD00185A.
Degradation of HaloTag-fused nuclear proteins using bestatin-HaloTag ligand hybrid molecules; S. Tomoshige, M. Naito, Y. Hashimoto, M. Ishikawa; Org. Biomol. Chem. 2015; 13: 9746-9750. https://doi.org/10.1039/C5OB01395J.
Superresolution Imaging of Targeted Proteins in Fixed and Living Cells Using Photoactivatable Organic Fluorophores; H.-I. D. Lee, S. J. Lord, S. Iwanaga, K. Zhan, H. Xie, J. C. Williams, H. Wang, G. R. Bowman, E. D. Goley, L. Shapiro, R. J. Twieg, J. Rao, W. E. Moerner; J. Am. Chem. Soc. 2010; 132(43): 15099-15101. https://doi.org/10.1021/ja1044192.
In Vivo Stable Tumor-Specific Painting in Various Colors Using Dehalogenase-Based Protein-Tag Fluorescent Ligands; N. Kosaka, M. Ogawa, P. L. Choyke, N. Karassina, C. Corona, M. McDougall, D. T. Lynch, C. C. Hoyt, R. M. Levenson, G. V. Los, H. Kobayashi; Bioconjug. Chem. 2009; 20(7): 1367-1374. https://doi.org/10.1021/bc9001344.
Direct pH measurements by using subcellular targeting of 5 (and 6-)carboxyseminaphthorhodafluor in mammalian cells; H. Benink, M. McDougall, D. Klaubert, G. Los; Biotechniques 2009; 47(3): 769-74. https://doi.org/10.2144/000113220.
Do you need larger quantities for your development or production?
Please send me more information about