Fmoc-N-ethyl-MPBA

Chemical name: 4-(4-(((9-Fluorenylmethyloxycarbonyl)(ethyl)amino)methyl)-3-methoxyphenoxy)butanoic acid // Synonyms: 4-(4-(((((9H-fluoren-9-yl)methoxy)carbonyl)(ethyl)amino)methyl)-3-methoxyphenoxy)butanoic acid, 4-(3-methoxy-4-[(Fmoc)(ethyl)aminomethyl]-phenoxy-butanoic acid

  • Product code:RL-3770
  • CAS No.:2173156-53-9
  • Formula:C29H31NO6
  • Molecular weight:489.87 g/mol

Starting at $942.50

Grouped product items
Qty Packing unit Price SKU
1 g
$942.50
RL-3770.0001
5 g
$3,770.00
RL-3770.0005
description

An ethyl-substituted MPBA linker derived from 4-hydroxy-3-methoxybenzaldehyde, which can be elongated using standard Fmoc-based solid phase chemistry and linked to supports by standard coupling procedures. The benzylic bond can be cleaved by addition of 90% TFA with appropriate scavengers.

This linker is reported for the synthesis of the N-alkylamine peptide Leuprolide.


references

Synthesis of a biologically active triazole-containing analogue of cystatin A through successive peptidomimetic alkyne-azide ligations; I. E. Valverde, F. Lecaille, G. Lalmanach, V. Aucagne, A. F. Delmas; Angew. Chem. Int. Ed. Engl. 2012; 51(3): 718-722. https://doi.org/10.1002/anie.201107222.


Biomimetic Screening of Class-B G Protein-Coupled Receptors; C. Devigny, F. Perez-Balderas, B. Hoogeland, S. Cuboni, R. Wachtel, C. P. Mauch, K. J. Webb, J. M. Deussing, F. Hausch; J. Am. Chem. Soc. 2011; 133(23): 8927-8933. https://doi.org/10.1021/ja200160s.


Backbone Amide Linker Strategy for the Synthesis of 1,4-Triazole-Containing Cyclic Tetra- and Pentapeptides; J. Springer, K. R. de Cuba, S.

Calvet-Vitale, J. A. J. Geenevasen, P. H. H. Hermkens, H. Hiemstra, J. H. van Maarseveen; Eur. J. Chem. 2008; 15: 2592-2600. https://doi.org/10.1002/ejoc.200800143.


An alternative method for the preparation of resin-bound secondary amines; R. E. Austin, C. A. Waldraff, F. Al-Obeidi; Tetrahedron Lett. 2002; 43(19): 3555-3556. https://doi.org/10.1016/S0040-4039(02)00569-5. 

Bulk or large quantity order?

Do you need larger quantities for your development or production?

Do you need further information about this product?

get in contact

Quick contact

Please send me more information about

We found other products you might like!