Biotin-Clip

Chemical name: N-(4-(((4-aminopyrimidin-2-yl)oxy)methyl)benzyl)-6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanamide // Synonyms: Biotin-BC, Biotin-Benzylcytosine

  • Product code:RL-3870
  • CAS No.:1004524-73-5
  • Formula:C28H39N7O4S
  • Molecular weight:569.73 g/mol

Starting at $260.00

Grouped product items
Qty Packing unit Price SKU
5 mg
$260.00
RL-3870.0005
25 mg
$1,040.00
RL-3870.0025
description

Biotin conjugated benzylcytosine (BC). The BC moiety reacts specifically and rapidly with the so-called CLIP-tag, a polypeptide protein tag, allowing irreversible and covalent labeling of clip fusion proteins with biotin. Biotinylated proteins can for example be selectively isolated based on the high affinity towards avidin representing a useful tool for purification, immobilization, and labeling.


references

A general method for the covalent labeling of fusion proteins with small molecules in vivo; A. Keppler, S. Gendrezig, T. Gronemeyer, H. Pick, H. Vogel, K. Johnsson; Nat. Biotechnol. 2003; 21: 86-89. https://doi.org/10.1038/nbt765.

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