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NTCB
Chemical name: 2-nitro-5-thiocyanatobenzoic acid
- Product code:RL-4080
- CAS No.:30211-77-9
- Formula:C8H4N2O4S
- Molecular weight:224.19 g/mol
- Purity :min.97%
Starting at $234.00
description
NTCB is a small molecule cyanylating reagent, which can be used for the activation of Cysteine and subsequent peptide hydrazide formation but also for the biorthogonal generation of Dehydroalanine via an E2 elimination reaction. This compound is light and moisture sensitive and should be stored under inert gas atmosphere.
references
Expressed Protein Ligation without Intein; Y. Qiao, G. Yu, K. C. Kratch, X. Aria Wang, W. Wei Wang, S. Z. Leeuwon, S. Xu, J. S. Morse, W. Ray Liu; J. Am. Chem. Soc. 2002; 142: 7057-7054. https://doi.org/10.1021/jacs.0c00252
Site-Specific Conversion of Cysteine in a Protein to Dehydroalanine Using 2-Nitro-5-thiocyanatobenzoic Acid; Y. Qiao, G. Yu, S. Z. Leeuwon, W. Ray Liu; Molecules 2021; 26: 2619. https://doi.org/10.3390/molecules26092619
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