DBCO-Suc-SS-COOH

Synonyms: DBCO-SS-COOH

  • Product code:RL-4110
  • CAS No.:2749426-25-1
  • Formula:C24H24N2O4S2
  • Molecular weight:468.59 g/mol

Starting at $585.00

Grouped product items
Qty Packing unit Price SKU
100 mg
$585.00
RL-4110.0100
250 mg
$1,170.00
RL-4110.0250
description

Disulfide-Based Linker bearing a clickable DBCO moiety and a carboxylic acid as functional group for crosslinking. The disulfide bond can be cleaved by reduction.

references

Linker Technologies for Antibody-Drug Conjugates; B. Nolting; Antibody-Drug Conjugates L. Ducry 2013; 1045: 71-100. https://doi.org/10.1007/978-1-62703-541-5_5

Current ADC linker chemistry; N. Jain, S. W. Smith, S. Ghone, B. Tomczuk; Pharm. Res. 2015; 32: 3526-3540. https://doi.org/10.1007/s11095-015-1657-7

Antibody drug conjugates: design and selection of linker, payload and conjugation chemistry; J. R. McCombs, S. C. Owen; AAPS J. 2015; 17(2): 339-351. https://doi.org/10.1208/s12248-014-9710-8

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