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TetraMe-Dioxoborolane-OpNC
Chemical name: 4-Nitrophenyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl carbonate
- Product code:RL-4130
- CAS No.:1254765-89-3
- Formula:C20H22BNO7
- Molecular weight:399.21 g/mol
Starting at $312.50
description
A self-immolative linker which can be cleaved upon reaction with/in the presence of H2O2.
references
Investigation of self-immolative linkers in the design of hydrogen peroxide activated metalloprotein inhibitors; J. L. Major Jourden, K. B. Daniel, S. M. Cohen; Chem. Commun. 2011; 47: 7968-7970. https://doi.org/10.1039/C1CC12526E
Reactive Oxygen Species-Responsive Protein Modification and Its Intracellular Delivery for Targeted Cancer Therapy; M. Wang, S. Sun, C. I. Neufeld, B. Perez-Ramirez, Q. Xu; Angew. Chem. Int. Ed. 2014; 53(49): 13444-13448. https://doi.org/10.1002/anie.201407234
Versatile Histochemical Approach to Detection of Hydrogen Peroxide in Cells and Tissues Based on Puromycin Staining; C. Yik-Sham Chung, G. A. Timblin, K. Saijo, C. J. Chang; J. Am. Chem. Soc. 2018; 140(19): 6109-6121. https://doi.org/10.1021/jacs.8b02279
Photoactivatable Organic Semiconducting Pro-nanoenzymes; J. Li, J. Huang, Y. Lyu, J. Huang, Y. Jiang, C. Xie, K. Pu; J. Am. Chem. Soc. 2019; 141(9): 4073-4079. https://doi.org/10.1021/jacs.8b13507
Reactive Oxygen Species-Responsive Liposomes via Boronate-Caged Phosphatidylethanolamine; J. Lou, M. D. Best; Bioconjugate Chem. 2020; 31(9): 2220-2230. https://doi.org/10.1021/acs.bioconjchem.0c00397
A mitochondrial-targetable dual functional near-infrared fluorescent probe to monitor pH and H2O2 in living cells and mice; X. Bi, Y. Wang, D. Wang, L. Liu, W. Zhu, J. Zhang, X. Zha; RSC Adv. 2020; 10: 26874-26879. https://doi.org/10.1039/D0RA03905E
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(Bi)functional dioxoborolane and disulfide-based self-immolative linkers – mode of action and application examples for the detection of H2 view details
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