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Smoc-L-Pro-OH

Chemical name: (((2,7-disulfo-9H-fluoren-9-yl)methoxy)carbonyl)-L-proline potassium salt // Synonyms: potassium (S)-9-(((2-carboxypyrrolidine-1-carbonyl)oxy)methyl)-9H-fluorene-2,7-disulfonate, Smoc-Pro-OH

  • Product code:SAA1150
  • CAS No.:2337407-20-0 (net)
  • Formula:C20H19NO10S2 (net)
  • Molecular weight:497,49 g/mol

Starting at $36.00

Grouped product items
Qty Packing unit Price SKU
5 g
$36.00
SAA1150.0005
10 g
$60.00
SAA1150.0010
New
description

Building blocks for aqueous solid-phase peptide synthesis (ASPPS). The 2,7-disulfo-9-fluorenylmethoxycarbonyl (Smoc) protecting group allows peptide synthesis using water instead of organic solvents – finally combining sustainability with cost optimization. The building blocks possess significant stability in basic aqueous solutions, but are easily losing their amino terminal protection upon mild treatment with particular water-soluble bases, e.g. NaOH, NH3, piperazine or ethanolamine. For ASPPS, a water-compatible resin, e.g. Tentagel, ChemMatrix, is required.


references

Method for peptide synthesis and apparatus for carrying out a method for solid phase synthesis of peptides; S. Knauer, T. M. L. Roese, O. Avrutina, H. Kolmar, C. Uth; 2016, WO 2016 050764.

Sustainable Peptide Synthesis Enabled by a Transient Protecting Group; S. Knauer, N. Koch, C. Uth, R. Meusinger, O. Avrutina, H. Kolmar; Angew. Chem. Int. Ed. 2020; 59(31): 12984-12990. https://doi.org/10.1002/anie.202003676.

Improved method for preparing peptides; S. Knauer; WO 2019 101939.

Method for preparing peptides; S. Knauer; WO 2019 101940.


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