Ph-BCP-NH2*HCl

Chemical name: 3-phenylbicyclo[1.1.1]pentan-1-amine hydrochloride

Product code:SCX1150
CAS No.:83249-11-0
Formula:C11H13N*HCl
Molecular weight:159,23*36,45 g/mol
Grouped product items
Qty Packing unit Price SKU
Please inquire Please inquire Please inquire SCX1150.0000
description
Phenol groups bearing drugs suffer rapid first-pass metabolism to glucuronide and sulfate conjugates, resulting in low bioavailability and low plasma concentrations.

An isosteric and biocompatible replacement of phenyl rings is the BCP moiety (bicyclo[1.1.1]pentane). This hypothesis has been successfully demonstrated in the case of Resveratrol: BCP-Resve ratrol shows significantly improved half-life in plasma and intrinsic clearance. Metabolite formation, like glucuronide and sulfate conjugation is drastically reduced.

references
Toward Resolving the Resveratrol Conundrum: Synthesis and in Vivo Pharmacokinetic Evaluation of BCP'2dResveratrol; Yi Ling Goh, Yan Ting Cui, Vishal Pendharkar, and Vikrant A. Adsool; ACS Med. Chem. Lett. 2017; 8: 516'2d520. DOI: 10.1021/acsmedchemlett.7b00018

A practical metal-free homolytic aromatic alkylation protocol for the synthesis of 3-(pyrazin-2-yl)bicyclo[1.1.1]pentane-1-carboxylic acid; Navanita T. Thirumoorthi and Vikrant A. Adsool ; Org. Biomol. Chem. 2016; 14: 9485-9489. DOI: 10.1039/c6ob01799a

Expedient synthesis of 3-phenylbicyclo[1.1.1]pentan-1-amine via metal-free homolytic aromatic alkylation of benzene; Navanita T. Thirumoorthi, Chew Jia Shen and Vikrant A. Adsool; Chem. Co mmun. 2015; 51: 3139-3142. DOI: 10.1039/c4cc09655j

Radical fluorination powered expedient synthesis of 3-fluorobicyclo[1.1.1]pentan-1-amine; Yi Ling Goh and Vikrant A. Adsool; this: Org. Biomol. Chem., 2015, 13, 11597- . DOI: 10.1039/c5ob02066b

A New Route to Bicyclo[1.1.1]pentan-1-amine from 1 Azido-3-iodobicyclo[1.1.1]pentane; Yi Ling Goh, Eric K.W. Tam, Paul H. Bernardo, Choon Boon Cheong, Charles W. Johannes, Anthony D. William, and Vikrant A. Adsool; Org. Lett. 2014; 16: 1884'2d1887. DOI: org/10.1021/ol500635p.

Bulk or large quantity order?

Do you need larger quantities for your development or production?

Do you need further information of this product?

get in contact

Quick contact

Please send me more information about

We found other products you might like!
Structure image for D-Biotin
D-Biotin

Starting at $60.75

Structure image for H-L-Hyp-pNA*HCl
H-L-Hyp-pNA*HCl

Starting at $337.50

Structure image for Biotin-OSu
Biotin-OSu

Starting at $114.75

Structure image for H-L-Lys(Boc)-pNA
H-L-Lys(Boc)-pNA

Starting at $114.75

Structure image for Boc-L-Lys(Z)-pNA
Boc-L-Lys(Z)-pNA

Starting at $256.50

Structure image for H-L-Leu-pNA
H-L-Leu-pNA

Starting at $270.00

Structure image for H-L-Phe-pNA*HCl
H-L-Phe-pNA*HCl

Starting at $81.00

Structure image for H-Gly-pNA
H-Gly-pNA

Starting at $60.75

Structure image for H-L-Lys(Z)-pNA
H-L-Lys(Z)-pNA

Starting at $128.25

Structure image for H-L-Pro-pNA*HCl
H-L-Pro-pNA*HCl

Starting at $162.00

Structure image for H-L-Glu(AMC)-OH
H-L-Glu(AMC)-OH

Starting at $210.60

Structure image for H-L-Ile-AMC*TFA
H-L-Ile-AMC*TFA

Starting at $405.00

Structure image for H-L-Glu(3CNA)-OH*NH3
H-L-Glu(3CNA)-OH*NH3

Starting at $371.25

Structure image for H-D-beta-HAla-OH*HCl
H-D-beta-HAla-OH*HCl

Starting at $236.25

Structure image for cyclo-DTT
cyclo-DTT

Starting at Please inquire

Structure image for DTT (L-Isomer)
DTT (L-Isomer)

Starting at Please inquire

Structure image for DTT (D-Isomer)
DTT (D-Isomer)

Starting at Please inquire

Structure image for Z-L-Phe-pNA
Z-L-Phe-pNA

Starting at $101.25

Structure image for H-L-Phe-pNA
H-L-Phe-pNA

Starting at Please inquire

Structure image for Fmoc-L-Glu-pNA
Fmoc-L-Glu-pNA

Starting at $121.50

Structure image for Fmoc-L-Glu-AMC
Fmoc-L-Glu-AMC

Starting at $109.35

Structure image for DAB
DAB

Starting at $256.50

Structure image for DAB*4HCl
DAB*4HCl

Starting at $256.50

Structure image for TCEP*HCl
TCEP*HCl

Starting at $256.50

Structure image for 5-Aminoindole
5-Aminoindole

Starting at $526.50

Fmoc-L-Asp-pNA
Fmoc-L-Asp-pNA

Starting at $135.00

Structure image for H-L-Met-AMC*TFA
H-L-Met-AMC*TFA

Starting at Please inquire

Structure image for H-L-Phe-AMC*TFA
H-L-Phe-AMC*TFA

Starting at Please inquire

Structure image for N-Acetyltryptamine
N-Acetyltryptamine

Starting at $202.50

Structure image for H-Gly-AMC
H-Gly-AMC

Starting at $108.00

Structure image for H-L-Leu-AMC
H-L-Leu-AMC

Starting at $108.00

(S)-HphVSPh*HCl
(S)-HphVSPh*HCl

Starting at Please inquire

Structure image for D-Desthiobiotin
D-Desthiobiotin

Starting at Please inquire

Structure image for Boc-L-Lys-AMC*AcOH
Boc-L-Lys-AMC*AcOH

Starting at $195.75

Structure image for H-L-Lys(Acryloyl)-OH
H-L-Lys(Acryloyl)-OH

Starting at $108.00

Structure image for H-L-Lys(Acryloyl)-OH*HCl
H-L-Lys(Acryloyl)-OH*HCl

Starting at $133.65

Structure image for Fmoc-L-Lys(Acryloyl)-OH
Fmoc-L-Lys(Acryloyl)-OH

Starting at $145.80

Structure image for H-Gly-L-Pro-pNA*TosOH
H-Gly-L-Pro-pNA*TosOH

Starting at $202.50

Structure image for BCP-NH2*HI
BCP-NH2*HI

Starting at Please inquire

Structure image for PhCO-BCP-NH2*HCl
PhCO-BCP-NH2*HCl

Starting at Please inquire

Structure image for F-BCP-NH2*HCl
F-BCP-NH2*HCl

Starting at Please inquire

Structure image for F-BCP-NH-Boc
F-BCP-NH-Boc

Starting at Please inquire

Structure image for H2NCH2-BCP-NH2*2HCl
H2NCH2-BCP-NH2*2HCl

Starting at Please inquire

Structure image for H2NCH2-BCP-CH2NH2*2HCl
H2NCH2-BCP-CH2NH2*2HCl

Starting at Please inquire