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Alkyne-palmitic acid
Nom chimique: 15-Hexadecynoic acid // Synonymes: Hexadec-15-ynoic acid
- n° Art.:RL-2060
- n° CAS:99208-90-9
- Formule:C16H28O2
- Masse moléculaire:252,39 g/mol
Starting at 400,00 €
description
Linker for bioconjugation via Click reaction. Protein acylation with this compound leads to rapid, selective and robust fluorescent detection with chemical reporters.
references
Robust fluorescent detection of protein fatty-acylation with chemical reporters. Charron G., Zhang M.M., Yount J.S., Wilson J., Raghavan A.S., Shamir E., Hang H.C.; J Am Chem Soc 2009; 131(13): 4967-4975. doi: 10.1021/ja810122f.
Rapid and selective detection of fatty acylated proteins using omega-alkynyl-fatty acids and click chemistry. Yap M.C., Kostiuk M.A., Martin D.D., Perinpanayagam M.A., Hak P.G., Siddam A., Majjigapu J.R., Rajaiah G., Keller B.O., Prescher J.A., Wu P., Bertozzi C.R., Falck J.R., Berthiaume L.G..; J Lipid Res 2010; 51(6): 1566-1580. doi: 10.1194/jlr.D002790.
SIRT6 regulates TNF-a secretion through hydrolysis of long-chain fatty acyl lysine. Jiang H., Khan S., Wang Y., Charron G., He B., Sebastian C., Du J., Kim R., Ge E., Mostoslavsky R., Hang H.C., Hao Q., Lin H.; Nature 2013; 496(7443): 110-113. doi: 10.1038/nature12038.
The biology and enzymology of protein N-myristoylation. Farazi T.A., Waksman G., Gordon J.I.; J Biol Chem 2001; 276(43): 39501-39504.
The growing impact of click chemistry on drug discovery. Kolb H.C., Sharpless K.B.; Drug Discov Today 2003; 8(24): 1128-1137.
Efficient construction of therapeutics, bioconjugates, biomaterials and bioactive surfaces using azide-alkyne click chemistry. Lutz J., Zarafshani Z.; Adv Drug Deliv Rev 2008; 60: 958-970.
Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives. Vila A., Tallman K.A., Jacobs A.T., Liebler D.C., Porter N.A., Marnett L.J.; Chem Res Toxicol 2008; 21(2): 432-444. doi: 10.1021/tx700347w.
Chemical Reporters of Protein Acylation. Howard C. Hang, Guillaume Charron, John P. Wilson, Anuradha Raghavan, Mingzi Zhang, Yu-Ying Yang, Kavita Rangan, Lun K. Tsou, Jacob Yount; US20100203647A1
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