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Thiolutin
Chemical name: Thiolutin from Streptomyces luteospores // Synonyms: N-(4-methyl-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3-b]pyrrol-6-yl)acetamide, Farcinicin, Propiopyvothine
- Product code:LS-3230
- CAS No.:87-11-6
- Formula:C8H8N2O2S2
- Molecular weight:228.29 g/mol
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description
Potent inhibitor of bacterial and yeast RNA polymerases. Inhibit in vitro RNA synthesis directed by all three yeast RNA polymerases (I, II, and III); inhibits mannan and glucan formation in Saccharomyces cerevisiae; used for the analysis of mRNA stability; inhibits adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin and suppresses tumor cell-induced angiogenesis in vivo.
references
Kebaara BW, Nielsen LE, Nickerson KW, Atkin AL.; Determination of mRNA half-lives in Candida albicans using thiolutin as a transcription inhibitor. Genome 2006; 49(8): 894-9.
Minamiguchi K, Kumagai H, Masuda T, Kawada M, Ishizuka M, Takeuchi T.; Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis. Int J Cancer 2001; 93(3): 307-16.
Sturdikova M, Proksa B, Uhrin D, Fuska J.; Regulation of biosynthesis of thiolutin and aureothricin in Streptomyces kasugaensis. Folia Microbiol (Praha) 1990; 35(4): 278-83.
Bergmann R.; Thiolutin inhibits utilization of glucose and other carbon sources in cells of Escherichia coli.; Antonie Van Leeuwenhoek 1989; 55(2): 143-52.
Jimenez A, Tipper DJ, Davies J.; Thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae. Mode of action.; Antimicrob Agents Chemother 1973; 3(6): 729-38.
Tipper DJ.; Thiolutin inhibits yeast ribonucleic acid polymerases; J Bacteriol 1973; 116(1): 245-56.
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