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Selective Lysine Labeling with Squaric Acid
Keeping control! PEGylating reagents with a squaric acid ethyl ester react chemoselectively with side chain amino functions of surface-accessible Lysines in proteins. Other functionalities are not affected.
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Process Development – From Discovery to Scale-up
Ongoing research efforts lead to the discovery of innovative building blocks and new APIs. However, for industrial applications, upscaling is required. Herein, we share the process development for Fmoc-Cys(Msbh)-OH.
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Workshop Bioorthogonal Chemistry in the Context of cell-free Protein Synthesis
You missed our workshop featuring Dr. Stefan Kubick (B4Pharmatech, Berlin)? Any further questions? Please get in contact via info@iris-biotech.de
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PotM: Multiconjugates via Simultaneous Double-Click Reaction
Discover our new building block 4-(azido-propyl-tetrazine)phenylalanine (pTAF) and make use of the orthogonality of the 2nd and 3rd generation Click reaction to build multiconjugates via double-Click.
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Conjugating Small Molecule Drugs
You want to attach your small molecule to a certain carrier? Let’s analyze the functional groups present and discuss Linkerology® possibilities for permanent or trigger-inducible, tracelessly-cleavable linkage.
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