Custom Synthesis

Wir führen kundenspezifische Synthesen von Labor- bis Produktionsmengen in den Gebieten unserer Expertise durch (ISO und cGMP); unsere besonderen Stärken sind Derivate mit einem oder mehreren chiralen Zentren.

Unsere Mission

ist, unsere Kunden während der Entwicklung ihrer Projekte vom Forschungsmassstab bis hin zur kommerziellen Produktion als qualifizierter Lieferant zu begleiten. Wir liefern deshalb Labormengen zu sehr günstigen Preisen und diese Produkte auch in Multi-KG Mengen und Tonnagen zusammen mit zunehmenden Bedarf an Analytikinformationen und Dokumentationen.

Unsere Produktionspartner

Wir kooperieren mit ca. 35 ausgewählten Herstellern und Universitäten, die jeweils weltweit führend sind auf ihrem jeweiligen Gebiet. Alle Produktionen gehen durch ein intensives und detailliertes Lieferantenqualifizierungsprogramm, bevor sie als Produktionsstätte registriert und qualifiziert sind.

Einige Beispiele für Auftragssyntheseprojekte finden Sie hier

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  1. Standard approaches Diethyl-acetamidomalonate Route: The probably most widely used first approach to unnatural amino acids goes via alkylation of diethyl acetamidomalonate. This process is daily routine in our laboratories and is an easy access to a large number of analogues in gram scale. This ...
  2. Specific platforms Asymmetric Phase-Transfer Reaction Phase-transfer alkylations e.g. with the chiral Maruoka catalyst result in unique α-mono substituted and α,α-disubstituted unnatural amino acids. Typically such building blocks implemented in peptides increase the chemical and metabolic ...
  3. Homologization of natural amino acids Several platforms are available to display the whole assortment of homo-amino acids, as well as the higher homologues β2-, β3-, their double substituted derivatives β2,2,2-, β3,3-, and corresponding γ-amino acids. Using e.g. via 4-benzyloxazolidin-2-one templates ...
  4. α-Methyl and β,β-dimethyl amino acids α-Methyl and alkyl-amino acids can be produced by a number of platforms, where the (2S,4S)-4-methyl-2-phenyloxazolidin-5-one scaffold is one of the most popular one. We optimize published procedures and have own proprietary ones, which enable us to supply all kinds of protected ...
  5. Trifluoromethylated and other Fluoro-amino acids The incorporation of trifluoromethyl group carrying building blocks into peptides results in increased chemical and thermal stability, increased resistance to degradation by proteases, and enhanced lipophilicity. Trifluoromethyl group bearing peptides will therefore show a better ...
  6. Arginine Analogues Trypsin (EC 3.4.21.4), an endopeptidase and natural protease found in the digestive system, cleaves peptide chains and proteins predominantly at the carboxyl side of the amino acids Lys and Arg (except when followed by Pro). Peptides and proteins are gaining importance as modern ...
  7. Proline Scaffold One role of proline in proteins is that a β-turn of a peptide chain is being induced at its position. Two major conformations, cis or trans, of the corresponding amid bond will induce that the protein folds in a specific way. While the trans-conformation is normally ...
  8. Specific Linkers The variations for linkers are endless, as in our catalogue program already hundreds of different derivatives are available for conjugation of small molecules, biomolecules and surfaces to each other. In the following we demonstrate a few examples with their specific properties. ...
  9. Spermines, spermidines and other Polyamines Polyamines such as ethylene diamine and its higher homologues are important feedstocks for the chemical industry. Compounds like putrescine, spermidine, and spermine play important roles in both eukaryotic and prokaryotic cells and show many other different biological functions. Most ...
  10. Maillard Reaction Products Proteins contained in meat and other comestible goods are usually rich in the amino acids arginine and lysine. The side chain func- tional groups of Arg and Lys react with reducing carbohydrates such as glucose or lactose to form Amadori reaction products. These characteristic ...
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