Articles by tag "Publication"

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Items 1 - 10 of 13 total

  1. Convenient method of peptide hydrazide synthesis using a new hydrazone resin Pavel S. Chelushkin, Ksenia V. Polyanichko, Maria V. Leko, Marina Yu. Dorosh, Thomas Bruckdorfer and Sergey V. Burov Tetrahedron Letters 2015; 56: 619–622; DOI: 10.1016/j.tetlet.2014.12.056 Abstract: Peptide hydrazides can be easily synthesized using a new hydrazone resin, obtained via ...
  2. Understanding enzyme immobilisation Ulf Hanefeld, Lucia Gardossi and Edmond Magner Chem. Soc. Rev.2009; 38:453–468; DOI: 10.1039/b711564b Abstract:Enzymes are versatile catalysts in the laboratory and on an industrial scale. To broaden their applicability in the laboratory and to ensure their (re)use in manufacturing the ...
  3. N-Fmoc-a-sulfo-b-alanine: a versatile building block for the water solubilisation of chromophores and fluorophores by solid-phase strategy Anthony Romieu, Thomas Bruckdorfer, Guillaume Clavé, Virgile Grandclaude, Cédrik Massif and Pierre-Yves Renard Org. Biomol. Chem.2011; 9:5337. DOI: 10.1039/c1ob05730h Abstract: An easy and efficient solid-phase synthesis strategy to obtain rapidly water-soluble ...
  4. Shorter Arginine homologues to stabilize peptides towards tryptic digestion Petra Henklein, Thomas Bruckdorfer Chemistry Today 2008; 26(6):12-15. Abstract: Trypsin digests peptides at the position of arginine. Because shorter homologues of arginine with appropriate protecting groups for conventional Fmoc/tBu peptide synthesis are now available, three model peptides ...
  5. A Three-Dimensional Quanititative Structure-Activity Relationship (3D-QSAR) Model for Predicting the Enantioselectivity of Candida antarctica Lipase B Paolo Braiuca, Knapic Lorena, Valerio Ferrario, Cynthia Ebert, and Lucia Gardossi Adv. Synth. Catal.2009; 351:1293 – 1302 Abstract:Computational techniques involving molecular modeling coupled with multivariate statistical analysis were used to evaluate and predict quantitatively the ...
  6. PEGylation - The Magic Wand IRIS Biotech GmbH - Turning Proteins and other Biopharmaceuticals into Super Performing Block Busters. Thomas Bruckdorfer PharManufacturing2007; 34-41 Abstract: In 2006 the market of modern biopharmaceuticals has reached a volume of over .3 billion in USA and over billion world wide (IMS Health, Inc.). It is projected to grow to an annual value of some billion within the next 5 years. The big ...
  7. Preparation of D-amino acids by enzymatic kinetic resolution using a mutant of penicillin-G acylase from E. coli Chiara Carboni, Hans G. T. Kierkels, Lucia Gardossi, Kamil Tamiola, Dick B. Janssen and Peter J. L. M. Quaedflieg Tetrahedron Asymmetry2006; 17:245–251 Abstract: We have demonstrated for the first time that D-glutamine (D-Gln) and D-glutamic acid (D-Glu) can be efficiently obtained in ...
  8. Hexafluoroacetone as Protecting and Activating Reagent: New Routes to Amino, Hydroxy, and Mercapto Acids and Their Application for Peptide and Glyco- and Depsipeptide Modification Jan Spengler, Christoph Böttcher, Fernando Albericio, and Klaus Burger Chem. Rev.2006; 106:4728-4746 Abstract: A considerable number of biologically active naturally occurring products are peptides, depsipeptides, and peptide conjugates. Peptide modification can be performed by backbone ...
  9. From Production of Peptides in Milligram Amounts for Research to Multi-Tons Quantities for Drugs of the Future Thomas Bruckdorfer, Oleg Marder and Fernando Albericio Current Pharmaceutical Biotechnology2004; 5:29-43 29 Abstract: Peptides are key to modern drug discovery. This article reviews the requirements for bulk production of peptides and how it affects research and production of smaller scales. ...
  10. Resin-bound mercapto acids: synthesis and application. Mourtas, Spyros; Gatos, Dimitrios; Karavoltsos, Manolis; Katakalou, Christina; Barlos, Kleomenis. Tetrahedron Letters2002; 43(18):3419-3421. Abstract: Mercapto acids were attached through their thiol group onto 2-chlorotrityl (Clt)-, trityl (Trt)-, 4-methyltrityl (Mtt)-, 4-methoxytrityl ...
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Items 1 - 10 of 13 total