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  • Custom Synthesis Fast & Efficient - from mg to multi-kg - Support & Service We carry out custom synthesis of complex organic molecules in the domain of our expertise. Non-GMP production from mg to multiple kg can be developed and transferred into GMP environment on demand. Our clients’ typical requirements range from simple one-step reactions to complex multi-step synthesis, with quantities form a few mg, only, to several kg. With qualified contract manufacturing companies we hav...
Knowledge Base
  • Barlos, Kleomenis; Mamos, Petros; Papaioannou, Dionysios; Patrianakou, Stella; Sanida, Chariklia; Schaefer, Wolfram. Liebigs Annalen der Chemie 1987; 12 :1025-30. Abstract: Ditrityl amino acids Trt-Lys(Trt)-OH (Trt = CPh3), Trt-Orn(Trt)-OH, Trt-Ser(Trt)-OH, and Trt-Hse(Trt)-OH were prepared and used in the synthesis of trityl-protected peptides, e.g., Trt-Ser(Trt)-Phe-NH2. Selective detritylation of the above amino acid derivatives and ditrityl peptides was achieved with 1% CF3CO2H in CH...
  • Pavel S. Chelushkin, Ksenia V. Polyanichko, Maria V. Leko, Marina Yu. Dorosh, Thomas Bruckdorfer and Sergey V. Burov Tetrahedron Letters 2015; 56 : 619–622; DOI: 10.1016/j.tetlet.2014.12.056 Abstract: Peptide hydrazides can be easily synthesized using a new hydrazone resin, obtained via acylation of aminomethyl polystyrene by Fmoc-hydrazone of pyruvic acid. It was shown that the hydrazone linker is completely stable in the course of standard Fmoc SPPS. Moreover, it can tolerate a tre...