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Hydrazone Resins provide a new and convenient method for the synthesis of peptide hydrazides, which can be applied during ligation techniques and glycosilation. It was shown that the hydrazone linker is completely stable in the course of standard Fmoc SPPS.
Moreover, it can tolerate a treatment with 5% TFA/DCM thus permitting selective removal of Mtt or related acid-labile protecting groups. Subsequent application of cleavage cocktails containing net TFA permits to obtain the desired peptides in a reasonable yields and purity.
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