Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Währung
EUR
Schneller Kontakt
Bitte senden Sie mir mehr Informationen über
Mal-Dap(Boc)-Val-Ala-PAB-PNP
Chemischer Name: N-alpha-Maleimido-N-beta-t-butyloxycarbonyl-L-2,3-diaminopropionyl-valyl-alanyl-(4-aminobenzyl)-(4-nitrophenyl)-carbonate // Synonyme: tert-butyl(S)-2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-((S)-3-methyl-1-((S)-1-(4-(((4-nitrophenoxy)carbonyloxy)methyl)phenylamino)-1-oxopropan-2-ylamino)-1-oxobutan-2-ylamino)-3-oxopropylcarbama te
- Art-Nr.:ADC1080
- Formel:C34H40N6O12
- Molare Masse:721,71 g/mol
Startet von 500,00 €
description
Linker for Antibody-Drug-Conjugation (ADC). The Val-Cit will specifically be cleaved by catepsin B. As this enzyme is only present in the lysosome the ACD payload will be release in the cell, only. MAL-Dap(Boc) building blocks are ideal tools for persistent conjugation with thiol groups: After removal of the Boc protecting group and conjugation with the mercaptane function, the free methylamino side chain will open the maleimide ring under aqueous conditions. While the conjugation reaction between thiol and cyclic maleimide is reversible, it turns completely stable in the open ring structure. This becomes particularly important in the formation of conjugates with high value components.
Please note the patent WO2013173337 for use of this compound in commercial applications, particular for antibody-drug conjugates.
references
Laurent Ducry (ed.), Antibody-Drug Conjugates, Methods in Molecular Biology, vol. 1045, DOI 10.1007/978-1-62703-541-5_5, # Springer Science+Business Media, LLC 2013.
Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates; R.P. Lyon, J.R. Setter, T.D. Bovee, S.O. Doronia, J.H. Hunter, M.E. Anderson, C.L. Balasubramanian, S.M. Duniho, C.I. Leiske, F. Li, P.D. Senter; Nature Biotechnology 2014; 32(10): 1059-1062. DOI:10.1038/nbt.2968.
WO2013173337
Bulk oder Großmengen-Bestellung?
Sie benötigen größere Mengen für Ihre Entwicklung oder Produktion?
Benötigen Sie weitere Informationen über dieses Produkt?
kontaktieren Sie uns
Verwandte Produkte
Broschüren & Flyer
Related news
-
News LinkerologyLinkerology® - An Example of Advanced Conjugation
The targeted delivery and traceless release of drugs is an important concept in pharmacology. Discover the possibilities of payloa
Details ansehen -
News Linkerology Product FocusEnzymatically Cleavable Linkers Based on Val-Cit and Val-Ala
Details ansehen
Produkte, die Sie auch interessieren könnten!
