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Building Blocks
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Deamino- and Decarboxy-Histidine Derivatives
Interested in histidine derivatives? Iris Biotech provides a selection of deamino- and decarboxy-products. Find out more about benefits and potential applications of our new building blocks.
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Building Blocks for the SPPS of FRET-based fluorogenic protease substrates
The classic FRET pair EDANS and DABCYL is now available linked to Fmoc amino acid building blocks that can be readily used in SPPS. Conveniently synthesize your own custom protease substrates!
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NGlyO – for beta sheet formation
Surprising behavior of NXO-peptides.
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It is a significant property of peptides that oxalo-retro azapeptides have the same donor and acceptor distances and properties for hydrogen bridge formation as a tripeptide fragment and therefore induce beta-sheet formation at this position.
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Peptoids - Peptide Backbone Derivatisation
Alkylating the Nitrogen of an amide bond results in peptoid structures, leading to conformational restrains, like N-methylation and allows backbone derivatisation. Applications already have been published with Cilengitide, Piscidin 1, and MC4 receptor agonist.
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Improved Synthesis with Dmb-Glycine Dipeptide Building Blocks
Positions next to Glycine are often reasons for side reactions, as aspartamide or diketopiperazine formation can occur. Dmb and Tmb can be used for temporary protection of the amide nitrogen of a peptide bond, in order to solubilize the peptide and increase yield and purity.
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Diamines & Polyamines
Compounds like putrescine, spermidine, and spermine play important roles in a many biological functions. Many of them are excellent targets for oncology studies and other fields of medicinal chemistry.
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Find in our new brochure Diamines & Polyamines our possibilities for custom synthesis and a set over 100 available derivatives.
