Published on 04.10.2018

Succinylation of proteins on the epsilon-amino group of lysine residues is a posttranslational modification that is still poorly understood.

Epsilon-succinyl lysine is known as a target of certain Sirtuins, a class of enzymes that has attracted attention for their role in metabolic regulation, disease pathogenesis and ageing. Synthetic succinyl lysine may aid in the understanding of the role of lysine succinylation, as well as in the further elucidation of Sirtuin function.

Succinyl modifications on proteins are removed by certain Sirtuins (R1, R2 = peptide chain).

→ Lysines with different epsilon-acyl groups are available via our Custom Synthesis service.


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