Acyl-Carnitine

Acyl-Carnitine

Published on 13.02.2013

Long-chain acylcarnitines are well-known intermediates in mitochondrial fatty acid oxidation

Long-chain acylcarnitines are well-known intermediates in mitochondrial fatty acid oxidation. Palmitoyl carnitine is a very potent specific inhibitor of protein kinase C (PKC), an important regulatory enzyme in several signal transduction cascades. Therefore, Palmitoyl carnitine has various physiological effects such as:

  • Modifies myocardial levels of high-energy phosphates and free fatty acids in the heart.1
  • Is a protector against cardiomyopathy.2
  • Acts on voltage, current, and contraction in ventricular cells.3
  • Has a biphasic effects on the open probability of L-type Ca channels, causing an increase in activity immediately after the addition of L-PC, but leading to a decrease in open probability after a few minutes.4
  • Has an anti-proliferative anti-tumor effect.5,6
LS-3320 LS-3345

 

LS-1370  

References:

  • Xiao C.Y. et al., Palmitoyl-L-carnitine modifies the myocardial levels of high-energy phosphates and free fatty acids. Basic Res. Cardiol. 1997; 92(5): 320-30.
  • Sayed-Ahmed M.M. et al., Propionyl-L-carnitine as protector against adriamycin-induced cardiomyopathy. Pharmacol. Res. 2001; 43(6): 513-20.
  • Shen J.B. and Pappano A.J., Palmitoyl-L-carnitine acts like ouabain on voltage, current, and contraction in guinea pig ventricular cells. Am. J. Physiol. 1995; 268: H1027-36.
  • Liu Q.Y. and Rosenberg R.L., Activation and inhibition of reconstituted cardiac L-type calcium channels by palmitoyl-L-carnitine. Biochem. Biophys. Res. Commun. 1996; 228: 252-8.
  • Nakadate T., Blumberg P.M., Modulation by palmitoylcarnitine of protein kinase C activation. Cancer Res. 1987; 47(24 Pt 1): 6537-42.
  • Vescovi G. et al., Modulation by palmitoyl-carnitine of calcium activated, phospholipid-dependent protein kinase activity and inhibition of melanoma cell growth. Br. J. Dermatol. 1988; 119(2): 171-8.