Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Währung
EUR
Schneller Kontakt
Bitte senden Sie mir mehr Informationen über
Fmoc-D-Sec(Xan)-OH
Chemischer Name: Fmoc-Se-xanthyl-D-selenocysteine // Synonyme: 2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(9H-xanthen-9-ylselanyl)-propionic acid, N-alpha-(9-Fluorenylmethyloxycarbonyl)-Se-xanthyl-D-selenocysteine, Fmoc-Sec(Xan)-OH
- Art-Nr.:FAA8600
- Formel:C31H25NO5Se
- Molare Masse:570,49 g/mol
- Reinheit:min. 98%
- Enantiomerenreinheit:min. 99,9%
Startet von 162,00 €
description
The 21st proteinogenic amino acid Selenocysteine (Sec, U) plays a crucial role for several biological processes. Fmoc-Sec(Xan)-OH represents a Selenocysteine derivative suitable for Fmoc SPPS bearing Xanthenyl (Xan) as TFA-labile sidechain protecting group.
As reported for Fmoc-Cys(Xan)-OH, Xanthenyl removal is triggered by exposure to dilute TFA in the presence of silane or thiol scavengers: 0.1% TFA for 1 h or 0.2% TFA for 10 min is sufficient when silane scavengers are used (Et3SiH is slightly better than iPr3SiH); 10% TFA is needed in conjunction with b-mercaptoethanol.
Furthermore, in contrast to Fmoc-Sec(Trt)-OH the xanthyl derivative Fmoc-Sec(Xan)-OH is reported to be bench-stable at room temperature for extended timeframes (> 1 month).
See also FAA8465 Fmoc-L-Sec(Xan)-OH
references
Novel S-xanthenyl protecting groups for cysteine and their applications for the N-alpha-9 Fluorenylmethyloxycarbonyl (Fmoc) strategy of peptide synthesis; X. Han, G. Barany; J. Org. Chem. 1997; 62: 3841-3848. https://doi.org/10.1021/jo961882g.
Fmoc-Sec(Xan)-OH: Synthesis and Utility of Fmoc Selenocysteine SPPS Derivatives with Acid-Labile Sidechain Protection; S. Flemer Jr.; J. Pept. Sci. 2015; 21: 53-59. https://doi.org/10.1002/psc.2723.
Bulk oder Großmengen-Bestellung?
Sie benötigen größere Mengen für Ihre Entwicklung oder Produktion?
Benötigen Sie weitere Informationen über dieses Produkt?
kontaktieren Sie uns
Verwandte Produkte
Broschüren & Flyer
Related news
-
News Amino Acids Building Blocks Product Focus ReagentsAbraligabra - Reagents and Building Blocks for Chemical Ligation
We can’t get enough of new products and innovations! Read this blog to get detailed information on the cyanylating reagent NTCB as well as seleno
Details ansehen -
-
News Product of the month Amino AcidsPotM: Seleno Amino Acids
Selenocysteine (Sec) plays a crucial role for various biological processes, and selenoproteins can be found in all lineages of life. Read on to dis
Details ansehen
Produkte, die Sie auch interessieren könnten!
