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Polysarcosine (PSR) – originating from the natural, non-toxic amino acid sarcosine (N-Methylglycine) – is the simplest polypeptoid and a newly rediscovered biocompatible and degradable polymer. Polysarcosine has been employed in a number of drug delivery systems, including dendrimers [1,2], polymer micelles [3,4], polyplexes , protein conjugates [6,7] and micro-[8-11] and nanoparticles [12-18], polymersomes  and nanotubes [20,21]. However, widespread use of PSR has been hampered by lack of commercially-available functional PSR in good quality.
The use of PSR with functional head- and tail-groups for bioconjugation is comparable to the well-known PEGylation technology.
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