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Fmoc-L-Dab(Alloc,Me)-OH
Chemischer Name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-N,N-gamma-allyloxycarbonyl-methyl-L-2,4-diaminobutyric acid // Synonyme: Fmoc-Dab(Alloc,Me)-OH, Fmoc-L-Dbu(Alloc,Me)-OH, Fmoc-Dbu(Alloc,Me)-OH, N-alpha-Fmoc-N,N-gamma-Alloc,Me-L-2,4-diaminobutyric acid, Fmoc-L-Dab(Aloc,Me)-OH, Fmoc-L-Dbu(Aloc,Me)-OH
- Art-Nr.:FAA8515
- CAS Nr.:2708344-13-0
- Formel:C24H26N2O6
- Molare Masse:438,48 g/mol
- Reinheit:min. 98%
- Enantiomerenreinheit:min. 99,7%
Startet von 168,00 €
description
This non-canonical amino acid serves as building block for solid-support peptide synthesis. N-Allyloxycarbonyl (Alloc) are widely used protecting groups, i.e. for amines and amino acids, as they are quantitatively and very rapidly converted to free amino compounds by palladium. Deprotection of allyl (All) carboxylates and allyl aryl ethers can also be carried out accordingly. All and Alloc are fully compatible with Fmoc/tBu and Boc/Bzl strategies, as well as with Z protecting groups.
references
Highly efficient removal of allyloxycarbonyl (Alloc) function provides a practical orthogonal protective strategy for carbohydrates; G. H. Zong, S. Q. Yan, X. M. Liang, J. J. Zhang, D. Q. Wang, F. Z. Kong; Chinese Chemical Letters 2009; 20: 127-130. https://doi.org/10.1016/j.cclet.2008.11.002.
Mild non-transition metal catalyzed deprotection of N-allyloxycarbonyl amines; R. H. Szumigala, E. Onofiok, S. Karady, J. D. Armstrong III, R. A. Miller; Tetrahedron Lett. 2005; 46(25): 4403-4405. https://doi.org/10.1016/j.tetlet.2005.04.064.
Allylic Protecting Groups and Their Use in a Complex Environment. Part II: Allylic Protecting Groups and their Removal through Catalytic Palladium π -Allyl Methodology; F. Guibé; Tetrahedron 1998; 54(13): 2967-3042. https://doi.org/10.1016/S0040-4020(97)10383-0.
Selective Cleavage of the Allyl and Allyloxycarbonyl Groups through Palladium-Catalyzed Hydrostannolysis with Tributyltin Hydride. Application to the Selective Protection-Deprotection of Amino Acid Derivatives and in Peptide Synthesis; O. Dangles, F. Guibe, G. Balavoine; S. Lavielle, A. Marquet; J. Org. Chem. 1987; 52(22): 4984-4993. https://doi.org/10.1021/jo00231a027.
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