Gly-CBT*HCl

Chemischer Name: 2-Amino-N-(2-cyano-6-benzothiazolyl)acetamide hydrochloride // Synonyme: CBT-Glycine, CBTG, Glycine-cyanobenzothiazole, Cyanobenzothiazolyl-glycine, 2-Amino-N-(2-cyanobenzo[D]thiazol-6-yl) acetamide, 2-amino-N-(2-cyano-1,3-benzothiazol-6-yl) acetamide,CBT-Gly

Art-Nr.:RL-4220
CAS Nr.:1207457-28-0 net
Formel:C₁₀H₈N₄OS*HCl
Molare Masse:232,26*36,45 g/mol

Startet von 300,00 €

Gruppiert Produkte - Artikel
Verpackungsgröße	Preis	SKU
100 mg	300,00 €	RL-4220.0100
250 mg	600,00 €	RL-4220.0250
1 g	1.800,00 €	RL-4220.1000

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description

The site-specific labeling of proteins by chemical reactions has gained increased interest for the investigation of cellular processes. In this regard, the CBT-Cys „click“ condensation reaction has found wide applicability in recent years. The reaction is highly biocompatible and controllable and runs under physiological conditions. It is based on the condensation between an N-terminal L- or D-Cysteine with the cyano group of CBT.

references

A Biocompatible Condensation Reaction for the Labeling of Terminal Cysteine Residues on Proteins; H. Ren, F. Xiao, K. Zhen, Y.P. Kim, H. Xie, Z. Xia, J. Rao; Angew. Chem. Int. Ed. 2009, 48: 9658-9662. https://doi.org/10.1002/anie.200903627

Genetically Encoded 1,2-Aminothiols Facilitate Rapid and Site-Specific Protein Labeling via a Bio-orthogonal Cyanobenzothiazole Condensation; J. Am. Chem. Soc. 2011, 133(30): 11418–11421. https://doi.org/10.1021/ja203111c

Site-specific immobilization of biomolecules by a biocompatible reaction between terminal cysteine and 2-cyanobenzothiazole; P. Wang, C.J. Zhang, G. Chen, Z. Na, S. Q. Yao, H. Sun; Chem. Commun. 2013, 49: 8644-8646. https://doi.org/10.1039/C3CC43566K

Sequence-Specific 2-Cyanobenzothiazole Ligation; C. P. Ramil, P. An, Z. Yu, Q. Lin; J. Am. Chem. Soc. 2016, 138 (17): 5499–5502. https://doi.org/10.1021/jacs.6b00982

Peptide cleavage induced assembly enables highly sensitive electrochemiluminescence detection of protease activity; M. Cheng, J. Zhuo, X. Zhou, D. Xing; Sens. Actuators B Chem. 2018, 262: 516-52. https://doi.org/10.1016/j.snb.2018.01.191

Injectable hyaluronic acid hydrogels encapsulating drug nanocrystals for long-term treatment of inflammatory arthritis; Y. Gao, D. Vogus, Z. Zhao, W. He, V. Krishnan, J. Kim, Y. Shi, A. Sarode, A. Ukidve, S. Mitragotri; Bioeng. Transl. Med. 2022, 7: e10245. https://doi.org/10.1002/btm2.10245

Affinity Bioorthogonal Chemistry (ABC) Tags for Site-Selective Conjugation, On-Resin Protein-Protein Coupling, and Purification of Protein Conjugates; S. L. Scinto, T. R. Reagle, J. M. Fox; Angew. Chem. Int. Ed. 2022, 61: e202207661. https://doi.org/10.1002/anie.202207661

Optimized molecular design of PET probe for the visualization of γ-glutamyltranspeptidase activity in tumors; X. Wang, D. Gao, C. Lu, M. Xie, J. Lin, L. Qiu; New J. Chem. 2022, 46: 10219-10228. https://doi.org/10.1039/D2NJ01688E