Name: Fmoc-L-Ser[Psi(Me,Me)Pro]-OH
SKU: FAA8590
Availability: InStock

Gruppiert Produkte - Artikel

Anzahl

Verpackungsgröße

Preis

SKU

5 g

125,00 €

FAA8590.0005

25 g

500,00 €

FAA8590.0025

100 g

1.500,00 €

FAA8590.0100

Sicherheitsdatenblätter

description

This building block is a pseudoproline monomer for SPPS. It can be successfully coupled with various amino acids using modern coupling techniques avoiding the need for pseudoproline dipeptides and giving the possibility to introduce pseudoprolines in peptides containing non-natural or rare amino acids. For coupling efficiency studies please see Senko et al, 2021.

references

Scope and limitations of pseudoprolines as individual amino acids in peptide synthesis; D. A. Senko, N. D. Timofeev, I. E. Kasheverov, I. A. Ivanov; Amino Acids 2021; 53: 665-671. https://doi.org/10.1007/s00726-021-02973-1.

Pseudo-Prolines as a Molecular Hinge: Reversible Induction of cis Amide Bonds into Peptide Backbones; P. Dumy, M. Keller, D. E. Ryan, B. Rohwedder, T. Wöhr and M. Mutter; J. Am. Chem. Soc. 1997; 119: 918-925. https://doi.org/10.1021/ja962780.

Pseudo-Prolines as a Solubilizing, Structure-Disrupting Protection Technique in Peptide Synthesis; T. Wöhr, F. Wahl, A. Nefzi, B. Rohwedder, T. Sato, X. Sun and M. Mutter; J. Am. Chem. Soc. 1996; 118: 9218-9227. https://doi.org/10.1021/ja961509q.

Expediting the Fmoc solid phase synthesis of long peptides through the application of dimethyloxazolidine dipeptides; P. White, J. W. Keyte, K. Bailey and G. Bloomberg; J. Pept. Sci. 2004; 10: 18-26. https://doi.org/10.1002/psc.484.

Pseudoprolines as Removable Turn Inducers: Tools for the Cyclization of Small Peptides; D. Skropeta, K. A. Jolliffe, and P. Turner; J. Org. Chem. 2004; 69: 8804-8809. https://doi.org/10.1021/jo0484732.