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Abstract: Ditrityl amino acids Trt-Lys(Trt)-OH (Trt = CPh3), Trt-Orn(Trt)-OH, Trt-Ser(Trt)-OH, and Trt-Hse(Trt)-OH were prepared and used in the synthesis of trityl-protected peptides, e.g., Trt-Ser(Trt)-Phe-NH2.
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In two joint studies together with Prof. F. Albericio we investigated the coupling efficiencies of Ser and Thr pseudoproline monomers and their use for the synthesis of inaccessible peptide sequenes. Read on!
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Herein, we report the first-time SPPS of a special peptide sequence via employment of of a serine pseudoproline building block as well as sec-isamyl mercaptan (SIT) as cysteine protecting group.
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Our portfolio currently contains over 5500 products. Many of them – in particular standard consumables for peptide synthesis – are being produced in bulk quantities. Therefore we can keep our prices also for lab quantities at very competitive level.
In case of need for bulk quantities please inquire:
- All 20 Proteinogenic Fmoc-protected Amino Acids are available in 100+ kg Lots;
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Phosphorylation of serine, threonine and tyrosine is counted among the most important posttranslational modifications that occur in organisms.
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Do not miss our special Christmas offer starting on December 1st!
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Our special Christmas offer is still valid! Get our standard L-amino acid bundle with 30% discount compared to standard prices. Choose your packaging unit!
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Sick of Lysine side chain protecting groups jumping around, yielding scrambled peptides? Check our various options to fine-tune protecting group stability vs. cleavability to optimize your peptide yield.
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You are working on complex peptides and are looking for a new level of orthogonality facilitating the overall synthetic process and improving your yields? Check out the Msbh safety-catch protecting group!
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Typically known and employed as preformed dipeptides, we are presenting Serine- and Threonine-derived Pseudoproline monomers as building blocks for solid-phase peptide synthesis.
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We now offer a series of Lysine dendrons for chemoselective functionalization of molecules containing carbonyl groups. These multivalent molecules carry diverse types of moieties, such as amine- or hydroxyl-groups, DOTA chelators or triphenylphosphonium (TPP) cations.
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Chiara Carboni, Hans G. T. Kierkels, Lucia Gardossi, Kamil Tamiola, Dick B. Janssen and Peter J. L. M. Quaedflieg
Tetrahedron Asymmetry: 2006; 17 : 245–251 https://doi.org/10.1016/j.tetasy.2005.12.023
Abstract: We have demonstrated for the first time that D-glutamine (D-Gln) and D-glutamic acid (D-Glu) can be efficiently obtained in high ee (97% and 90%, respectively) by enzymatic kinetic resolution of D,L-Gln and D,L-Glu. This was achieved by enantioselective conversion of...
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Interested in histidine derivatives? Iris Biotech provides a selection of deamino- and decarboxy-products. Find out more about benefits and potential applications of our new building blocks.
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Discover the versatile applications of hydrazone resins e.g. for the preparation of peptide hydrazides, or the generation of peptide thio esters. Read on to find out more and see our available products.
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Discover our small-sized, neutral Fmoc-protected nitrobenzoselenadiazole- and nitrobenzothiadiazole-modified amino acids suitable for SPPS of fluorescent peptides.
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Serine- and Threonine-derived oxazolidines as well as Cysteine-derived thiazolidines, so-called Pseudoprolines, serve as structure-disrupting, solubilizing building blocks in peptide synthesis.
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Add a new dimension of orthogonality to your peptide synthesis by using Safety-Catch arylalkyl sulfoxide protecting groups! This newsletter tells you about benefits and usage – Read on!
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Herein we are presenting 2-(Fmoc-amino)-3,3-diMe-pent-4-enoic acid (FAA5040), a protease stable Ile/Leu surrogate suitable for further modification via its side chain double bond.
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Oligo-glycines are either flexible linkers or form well defined rigid substructures. We offer a variety of oligo-glycines as building blocks which can easily be introduced into any molecule.
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The tremendous success of Liraglutide and Semaglutide has moved amino acids modified with lipids into the focus of many research endeavors. Delve into the treasure trove of our lipidated amino acids!
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Iris Biotech presents the next-generation of hydrolysis-stable phosphono-analogs of pSer, pThr and pTyr. Fluorination renders the phosphonic acid more acidic and thus an even better mimic of the parent phosphoamino acid.
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Ongoing research efforts lead to the discovery of innovative building blocks and new APIs. However, for industrial applications, upscaling is required. Herein, we share the process development for Fmoc-Cys(Msbh)-OH.
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Pressemitteilung ( pdf Download-Version )
IRIS Biotech bringt neue Innovationen auf den Markt
Das in Marktredwitz in Oberfranken/Ostbayern beheimatete Unternehmen IRIS Biotech GmbH hat durch Intensivierung seiner Zusammenarbeit mit Forschungsinstitutionen den Zeitraum der Markteinführung neuer Produktgruppen drastisch verkürzt. Derzeit kooperiert das Unternehmen mit 35 ausgewählten Herstellern und Universitäten aus aller Welt...
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Press release (german text, pdf Download-Version )
IRIS Biotech bringt neue Innovationen auf den Markt
Das in Marktredwitz in Oberfranken/Ostbayern beheimatete Unternehmen IRIS Biotech GmbH hat durch Intensivierung seiner Zusammenarbeit mit Forschungsinstitutionen den Zeitraum der Markteinführung neuer Produktgruppen drastisch verkürzt. Derzeit kooperiert das Unternehmen mit 35 ausgewählten Herstellern und Universitäten aus aller Welt...
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Building Blocks for the synthesis of 2,3-diaminobutanoic acid containing peptides or for Click reactions.
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A prominent luciferase group was first discovered in Coelenterata and the corresponding light emitting molecule was therefore named coelenterazine.
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The azido function can be used for different applications
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June 10th-12th, 2013 Auditorio AXA Barcelona, Spain
Barcelona meeting will be fifth in a series – after Rimini (2005), Wroclaw (2007), Frankfurt (2009) and Budapest (2011) – and will put together scientists from different backgrounds in order to facilitate translation of knowledge from chemistry to biology.
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Aryl azides are well-known precursors of nitrenes and have been introduced by Fleet et al . as versatile photoaffinity labeling agents to probe biological receptors.
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Dess-Martin-Periodinane is one of the most useful reagents for the reduction of primary and secondary alcohols to aldehydes and ketones.
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Any amino acid can be functionalized on the N-terminus with oxalic acid and on the C-terminus with hydrazine, in order to form a so-called NXO building block. Through this double modification N and C terminus will be inverted, which provides interesting structural options for peptidomimetics.
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February 10th-11th, 2014 Ghent, Belgium
This meeting intends to cover various aspects of peptide research: synthesis, identification, pharmacology, drug discovery and development, delivery, peptide production,... etc.
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A set of new statin analogues, so called Super-Threonines, is available consisting of Fmoc protected L-enantiomers with all possible 4 stereoisomers of chiral centers in the side chain. They appear in nature as bridge building element in cyclodepsipeptides, like pipecolidepsin A, a compound which shows relevant cytotoxic activity in three human tumor cell lines (lung, colon, breast) and has unique structural features.
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Tyramine compounds are converted to highly reactive radicals by horseradish peroxidase in presence of H2O2 which preferentially react with surface exposed tyrosines. Biotin Tyramide and Biotin-PEG-Tyramide therefore are ideal reagents used for tyrosine-/protein-biotinylation.
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For most of our products Safety Data Sheets are available online now. Find them in five languages: English / French / German / Spanish / Czech . Simply log in to your account on our webpage and find them on the product description pages.
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May 19th - 21th, 2014 Centro de Investigación Príncipe Felipe Valencia, Spain
Unlike other Drug Delivery Symposia that have a broader remit, this unique conference series was specifically established to provide a forum for interdisciplinary exchange of state-of-the-art techniques and advances in knowledge relating to the design, clinical development and commercialisation of Polymer Therapeutics.
The key topics discussed during the 10th International Symposium on Polymer Therapeutics are...
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May 28th - 30th, 2014 KINTEX, Exhibition Center II Kintex, Korea
BIO KOREA 2014 Conference is a worldwide accepted venue and place to discuss and acquire the cutting edge knowledge on various topics including vaccines, clinical trials, regenerative medicine, bio energy, GMO, functional food, technology transfer and licensing to firmly secure the global competitiveness.
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Benzotriazol activated carboxylic acids:
Fast reaction (within minutes) at room temperature with amines and other nucleophiles under addition of base (in both water and non- aqueous solvents).
Stable to racemization when coupling with nucleophiles.
High solubility in organic solvents like DMF and DCM.
Stable in water.
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In modern biotechnology there are numerous applications for the luminogenic luciferase assay. We supply luciferin from mg scale for research applications like monitoring of gene expression or tumor growth up to kg quantities for hygiene surveillance in food industry
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July 13th - 18th, 2014 SOCRATE Auditorium Louvain-la-Neuve, Belgium
The BOSS -conference is a unique international symposium as it combines lectures delivered by established organic chemists as well as younger rising stars with two prestigious events: a lecture delivered by the recipient of the “Janssen Pharmaceutica Prize for Creativity in Organic Synthesis”, and the “Tetrahedron Chair”: a one-day course on a specific topic in organic synthesis.
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1,4-substituted 1,2,3-triazole are isosteric to peptide bonds and result in peptide mimetics which even retain activity e.g. in case of certain tyrosinease inhibitors.
We offer custom synthesis of Alkyne Amino Acid Analogues as building blocks for triazol formation via Click conjugation. Side chains can represent all natural amino acids or unusual residues. In combination with our alpha-azido acids we can offer the whole range of building blocks to design Click-peptide bond analogues for every proteinoge...
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October 7th - 9th, 2014 Paris Nord Villepint Paris, France
Join us in Paris for CPhI Worldwide 2014 , the world's leading pharmaceutical networking event, co-located with ICSE, P-MEC and InnoPack.
CPhI Worldwide hosts 2,500 exhibitors and 35,000 attendees from 140 countries.
Meet face-to-face with international pharmaceutical companies, stay informed about the latest industry trends and remain one step ahead of a constantly changing pharmaceutical market.
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Cleavable dipeptide linkers like Val-Ala and Val-Cit rely on processes inside the cell to liberate the payload, as they undergo rapid hydrolysis in the presence of lysosomal extracts or purified human cathepsin B.
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Pseudoprolines derived from Serine and Threonine have developed to standard building blocks for peptide synthesis since their invention. Now this technology is also available with Cysteine residues, as the corresponding 2,4-dimethoxyphenyl-pseudothiaproline is compatible with standard Fmoc/tBu protocols.
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June 8th - 11th, 2015 University of Lorraine, Campus du Saulcy Metz, France
The Bioheterocycles 2015 - XVI International Conference on Heterocycles in Bioorganic Chemistry is a continuation of the series started by Professor Henk van der Plas in 1980. Since that time the boundaries of bio-organic chemistry have been expanded significantly and we feel it is time to learn about the latest progress in the field. The objective is to facilitate fruitful interaction of young scientists with internat...
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We at Iris Biotech, are pleased to announce that we have entered into an agreement with Peptide Solutions, LLC to sell the complete line of our products in the USA and Canada.
Peptide Solutions’ website has a link to our complete list of products so ordering online is extremely easy, however, personal contact is available at the phone listed above, Monday through Friday, 8am to 5pm MST.
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June 10th - 12th, 2015 Reitoria of Universidade Nova de Lisboa Campus de Campolide, Lisboa, Portugal
The 6th European Conference on Chemistry for Life Sciences (6th ECCLS) will be held in Lisbon, Portugal, in June 10-12, 2015. Lisbon meeting will be sixth in a series – after Rimini (2005), Wroclaw (2007), Frankfurt (2009), Budapest (2011) and Barcelona (2013) – and will put together scientists from different backgrounds in order to facilitate translation of knowledge between chemi...
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June 15th - 18th, 2015 Pennsylvania Convention Center Philadelphia, PA, USA
The BIO 2015 covers the wide spectrum of life science innovations and application areas. Drug discovery, biomanufacturing, genomics, biofuels, nanotechnology and cell therapy are just a few of the industries represented at the BIO International Convention.
The four key elements of the event are:
BIO Education Program
Networking Events
BIO One-on-One Partnering TM
BIO Exhibtion
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A new hydrazone resin enables a convenient way to synthesize peptide hydrazides for Hydrazone Ligation Technique and Native Chemical Ligation (NCL).
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Visit our Glycine section and find a series of amino acid derivatives, where oxazole is the characteristic structural element carrying carboxy and amino function.
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Visit our Glycine section and find a series of amino acid derivatives, where oxazole is the characteristic structural element carrying carboxy and amino function.
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Surprising behavior of NXO-peptides.
It is a significant property of peptides that oxalo-retro azapeptides have the same donor and acceptor distances and properties for hydrogen bridge formation as a tripeptide fragment and therefore induce beta-sheet formation at this position.
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October 13th - 15th, 2015 Feria de Madrid, Spain
Join us in Paris for CPhI Worldwide 2015 , the world's leading pharmaceutical networking event, co-located with ICSE, P-MEC and InnoPack.
CPhI Worldwide hosts 2,500 exhibitors and 35,000 attendees from 140 countries.
Meet face-to-face with international pharmaceutical companies, stay informed about the latest industry trends and remain one step ahead of a constantly changing pharmaceutical market.
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October 7 to 9 2015 Melbourne, Victoria, Australia https://www.ausbiotech.org/
AusBiotech represents 3000 members covering the human health, agricultural, environmental, industrial, medical device, functional foods and Investment sectors in biotechnology. Over 150 events for the life science sector provide unique networking opportunities through business matching programs, sponsorship and guest speaker roles.
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Bulky glycine analogs are interesting molecules for creating peptide derivatives with certain biological activities, e.g. with antiviral properties. Furthermore, they are useful compounds for protein structure evaluation.
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Click chemistry is a convenient method to chemoselectively functionalize peptides at specific positions. We offer a variety of different propargyl amino acids for both Fmoc and Boc strategies, for enzymatic synthesis, as well as preloaded resins for SPPS.
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Our new Biotin-SS-Tyramide linker is a valuable tool for peroxidase-promoted targeted protein biotinylation. By using peroxidase-tagged antibodies, proteins and protein clusters can be selectively biotinylated, and then isolated using streptavidin. The biotin tag can be subsequently removed using reducing agents (e.g. glutathione).
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Asymmetric Rhodamine 110 protease substrates are used for the determination of protease kinetics. The asymmetric structure of these dyes greatly simplifies the determination of enzyme kinetics, while the properties of Rhodamine 110 facilitate an uncomplicated readout.
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Maillard Reaction Products (MRPs) result from the reaction of Arg and Lys side chains with reducing carbohydrates. MRPs are valuable markers for food quality and are used in many different branches of industry such as food, pharma, cosmetics and biochemistry.
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The reaction between a tetrazine (Tz) and a trans -cyclooctene (TCO) is the innovative third generation Click reaction that proceeds without the use of copper or other catalyst. It is rapid, fully bioorthogonal and excels at very low concentrations.
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June 6th - 8th, 2016 Moscone Center - South hall San Francisco, CA, USA
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Omniligase-1 enables efficient and racemization-free ligation of two side-chain unprotected peptide fragments at many different positions. Test this innovative enzyme developed by EnzyPep B.V. using the complementary model peptides included in our kit!
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10-13 October 2016 San Diego, CA, USA Marriot Marquis & Marina
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Conjugates of PEG and folic acid or cholesterol, respectively, combine the positive properties of these molecules. Those conjugates are available with a wide variety of functional groups and different PEG chain lengths to suit your needs.
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Fmoc-L-Dap(2-Boc-aminoethyl)-OH is the first in a series of new triamino acid building blocks. This azalysine is useful for introducing positive charges into a peptide, or for creating branched structures.
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19 - 22 June 2017
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5 - 7 July 2017
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Polylysines are polymers of the canonical amino acid Lysine, and are characterized by their high charge density caused by the presence of one free amino group per lysine monomer.
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Poly-(α-L-glutamic acid) is a synthetic polypeptide of L-Glu linked by the alpha-amino groups (α-PGA). These polyanionic and biodegradable polymers can be used for a variety of purposes.
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The Fmoc group is the most frequently used protecting group in peptide chemistry. The most common deprotection conditions involve a solution of 20% piperidine in DMF.
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May 7-10, 2018
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The use of bioactive peptides has increased over the recent years as they attracted attention for their use as therapeutic agents.
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Iris Biotech introduces a comprehensive set of photo-crosslinking amino acids bearing the diazirine moiety.
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Indocyanine Green (ICG) dye, a material approved by the FDA for various applications, is a powerful tool for imaging in live cells and tissues .
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Find below derivatives of arginine and lysine bearing side chains as found in Maillard reaction products.
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8 – 10 November 2018
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Succinylation of proteins on the epsilon-amino group of lysine residues is a posttranslational modification that is still poorly understood.
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Methods for proteomic mapping of cellular organelles or subdomains that avoid the necessity of cell lysis and purification by targeting specific subcellular regions have several advantages.
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Protease inhibitors are molecules that inhibit protease function by binding either reversibly or irreversibly to the enzyme.
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The Allocam protecting group allows for selective deprotection and disulfide bond formation on-resin in one step.
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Two selected publications were summarized in this article in order to highlight the impressive utility of amino acids incorporating the diazirine photophore.
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5 - 7 September 2019
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12 - 15 November 2019
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Wir freuen uns Ihnen unsere drei neuen Teammitglieder vorstellen zu dürfen:
Frau Lusine Davtyan (li.) absolviert bei der Cfm Oskar Tropitzsch GmbH ein 6 monatiges Praktikum im Bereich Gesundheitsmanagement.
Frau Celine Pohlers (mi.) begann eine Ausbildung bei der Cfm Oskar Tropitzsch GmbH als Kauffrau Groß- und Aussenhandel, Fachrichtung Aussenhandel.
Frau Sina Weichold (re.) begann die selbe Ausbildung bei der Iris Biotech GmbH.
Wir wünschen unseren jungen Mitarbeiterinnen viel Freude bei ...
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August 27th - 28th 2020
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Peptide purification after SPPS usually requires time- and solvent-consuming HPLC, which is often limited by co-eluting side-products. Belyntic’s catch-and-release PEC-Linker chemoselectively catches the desired product from your crude to reach a new dimension of purity.
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Sidechain-derivatized amino acids have shown great potential in enhancing select properties of peptide lead compounds. Find the most recent additions to our portfolio of amino acids bearing additional aryl and alkyl groups in their side chains.
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The integrin receptor interacting RGD sequence and related peptides act as promising tools for drug therapy and cancer research. Find more information on our portfolio of cyclic RGD peptides.
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Alkyne amino acids allow for Click conjugations and other types of chemistry. Read more about alkyne-functionalized amino acids and our related products.
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The ever-growing sophistication and variation in linker design have given rise to a new and distinct field of knowledge in synthetic chemistry termed Linkerology. Discover our expertise and panoply of new cutting-edge tailor-made linker constructs for the latest state-of-the-art bioconjugations.
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We, Iris Biotech GmbH, are pleased that Dr. Thomas Bruckdorfer completes the BIOPARK8-Brain-Network in Regensburg and will enrich it with our experience.
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Find out which Maillard Reaction Products from Iris Biotech were used in the development of a state-of-the-art analytical method for 15 different AGEs.
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Amongst various somatostatin analogues, the pentacyclic heptapeptide TT-232 bears unique properties. Iris Biotech offers TT-232 as triacetate and trifluoroacetate salt, respectively, as well as conjugated to either biotin or the fluorophore indocyanine green.
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Learn, how His-Tag can be used for specific linker attachment. Another example in our LINKEROLOGY series of sophisticated linker technologies.
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Find out more about those building blocks with side chains able to coordinate metal ions, and why peptide-based HDACis are intriguing synthetic targets.
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Looking to optimize or functionalize your peptide? Explore our ever-growing selection of Arg derivatives and find the one suitable for your application.
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Iris Biotech presents (functionalized) fullerenes of different core size (C60 vs. C70) as versatile tools for multiple functionalization. Read more about their unique properties and fields of applications.
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Polyamines such as ethylene diamine and its higher homologues are important feedstocks for the chemical industry. Compounds like putrescine, spermidine, and spermine play important roles in both eukaryotic and prokaryotic cells and show many other different biological functions.
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Trypsin (EC 3.4.21.4), an endopeptidase and natural protease found in the digestive system, cleaves peptide chains and proteins predominantly at the carboxyl side of the amino acids Lys and Arg (except when followed by Pro).
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The incorporation of trifluoromethyl group carrying building blocks into peptides results in increased chemical and thermal stability, increased resistance to degradation by proteases, and enhanced lipophilicity.
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α-Methyl and alkyl-amino acids can be produced by a number of platforms, where the (2S,4S)-4-methyl-2-phenyloxazolidin-5-one scaffold is one of the most popular one.
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Click Chemistry in DNA Synthesis - Applications and Procedures in DNA Synthesis
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The azido group can be reduced to an amino function and hereby serve as masked amino group. It is of particular use if additional orthogonalities are needed. Azido is stable towards treatment with piperidine (Fmoc deprotection), Pd(0) (Alloc removal) and acidic treatmet (cleavage of Mtt, Trt or other acid sensitive groups). However, as it is a pseudohalogenide, care has to be taken during coupling steps, as HATU will cause high racemization. This can be avoided using collidine or other non-nucleophilic bas...
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As Boc and Fmoc protected derivatives of both azido and alkyne amino acids are available, they can be introduced into peptide sequences through standard SPPS protocols, for example. In an α-helical secondary structure amino acids at positions i and i+4 are above each other.
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Mercapto-PEG-Acids are highly hydrophilic, non-antigenic, non-immunogenic and non-toxic.
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PEGs show a spectrum of unique physical and chemical properties, which have been described in literature extensively by the pioneers in PEGylation: Harris, Veronese and recently by Hermanson. Here are summarized the most common known properties.
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Potential alternatives to PEGs, polypeptoids in general and polysarcosine (PSR) in particular stand out in terms of safety, synthetic control and versatility.
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Small drug molecules and also large biomolecules like proteins or antibodies suffer rapid clearance from human body.
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Peptide hydrazides can be easily synthesized using a new hydrazone resin, obtained via acylation of aminomethyl polystyrene by Fmoc-hydrazone of pyruvic acid.
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Abstract: A symposium report. Protected peptides were synthesized using 9-fluorenylmethoxycarbonyl (Fmoc) amino acids and the acid labile 2-chlorotrityl and the multidetachable 2-chlorotrityl-Rink-linker resins.
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Iris Biotech presents its selection of Val-Cit-based linkers, a dipeptide motif frequently utilized for the development of ADCs with increased serum stability and high cleavage efficiency.
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Iris Biotech offers various linked kinase inhibitors including analogues of Gefitinib, Imatinib, Sunitinib, Staurosporine and many more, which can easily be conjugated to other biomolecules, if desired. Have a look and read more.
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One approach for the design of bioactive peptides with improved pharmacological properties is the derivatization of amino acid building blocks with fluorine. Find out more about the advantages of fluorinated peptides.
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Methionine is particularly prone to oxidation by atmospheric oxygen in vitro but also by reactive oxygen species in vivo, resulting in the corresponding sulfoxide and sulfone. Read on to find out more.
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Interested in the formation of peptide thioesters for Native Chemical Ligation? Read on to find out more about the use of Dawson Linker derivatives as thioester surrogates compatible with Fmoc SPPS.
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January 19, 2021
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Cyclopropanes represent important design elements in medicinal chemistry and are widely present in drug compounds. Read on to find out more about their full potential.
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Frustrated by aspartimide formation during peptide synthesis? Iris Biotech presents aspartate derivatives with bulky side chain protecting groups that minimize the formation of aspartimide-related side-products.
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Herein we present two arginine derivatives, in which the native guanidino group is replaced by an isosteric amino-functionalized carbamoylated guanidino group that can serve as an attachment point for further derivatization.
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An efficient, versatile linker developed for the synthesis of C-terminal primary/secondary amides and hydrazides as well as peptide alcohols, which is compatible with SPPS and suppresses side reactions.
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Herein we present substituted diazacyclononynes (DACNs) as versatile tools for metal-free strain-promoted Click Chemistry that are characterized by high reactivity and stability, both thermally and chemically.
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Interested in studying the effect of palmitoylation on your peptide’s localization, function, and stability? Read on to find out more about the use of lipidated “fatty” amino acids!
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Iris Biotech offers various (protected) azide- and alkyne-modified fatty acid derivatives suitable for Click Chemistry. Interested? Read on to find out more!
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Interested in structure-activity studies of your Proline-containing peptide drug? Find out more about the use of Methanoprolines and Dimethylprolines as conformational amide locks.
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The incorporation of alpha-trifluoromethyl substituted amino acids into peptides increases proteolytic stability, enhances lipophilicity, and induces secondary structures. Read on to find out more!
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The peptide-based ADC linkers Val-Cit and Val-Ala are efficiently cleaved by lysosomal proteases and benefit from increased serum stability and effective payload-release in targeted cells.
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Compounds of the shown formula can simply be bound to solid supports via amide bond formation without racemization of the C-terminal amino acid and enable the synthesis of very pure peptides.
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Herein, we present Fmoc-protected N-alkyl-substituted carboxy linkers, which can be elongated by Fmoc-SPPS and can easily be linked to amino-functionalized solid supports. Read on to find out more about their advantages.
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Iris Biotech offers a variety of (functionalized) biotin and desthiobiotin reagents reactive towards certain functional groups. Discover our growing portfolio and latest additions.
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Aspartimide formation remains one major hurdle during peptide synthesis. Read on to find out more about different strategies and available products at Iris Biotech in order to avoid this side product.
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Selenocysteine (Sec) plays a crucial role for various biological processes, and selenoproteins can be found in all lineages of life. Read on to discover the 21 st amino acid, its derivatives and applications.
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Polysarcosines (PSars) – a true alternative to polyethyleneglycols (PEGs) - stand out in terms of safety, synthetic control, and versatility. Interested? Read on to find out more about their properties.
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Check out our growing portfolio on adamantyl-substituted amino acids and building blocks. At Iris Biotech, we are constantly striving to improve our services, our products, and the routes of synthesis.
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Herein we present a series of alpha,alpha-cycle-disubstituted amino acid derivatives used in peptide design for their structure promoting effects as well as conformational rigidity.
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Herein, we summarize certain product highlights and innovations, which we presented in our newsletters 2021. Have a look and get in contact for more information or an individualized offer.
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Discover our selection of substrates for Halo-, Snap-, and Clip-tagged proteins bearing different terminal groups suitable for further functionalization, e.g. biotinylation and Click chemistry.
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Stable isotopically labeled drugs are routinely used to investigate a drug’s metabolism, distribution, bioavailability, side effects and potential toxicity. Discover our selection of labeled drugs.
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Looking for an acid stable protecting group? Struggling with undesired loss of the Cbz protecting group while removing Boc under acidic conditions? Read on to find out more about iNoc as alternative.
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Interested in polymers for the delivery of promising drug candidates, e.g. nucleic acids? Discover our selection of lipidated polyamino acids and custom capabilities. Read on to find out more!
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We are providing variously functionalized, protected and unprotected fatty acid derivatives suitable for SPPS and further conjugation, e.g. via Click chemistry. Read on to discover our portfolio.
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Iris Biotech offers the main building blocks for the synthesis of Liraglutide and Semaglutide and commonly observed impurities as well as reference standards. Read on for more information!
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Iris Biotech is your trusted partner in the world of peptides and all related disciplines. Your project requires a compound not listed in our portfolio? Get in contact and inquire for a custom synthesis!
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Discover our products suitable for drug delivery including poly ethyleneglycols (PEGs), poly amino acids (PArg, PGlu, PLys, POR, PSar), poly(oxazoline)s, as well as fullerenes. Read on to find out more!
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You missed our workshop featuring Prof. María Jesus Vicent Docón (Head of Polymer Therapeutics Lab)? Any further questions? Please get in contact via info@iris-biotech.de.
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Photoswitches grant the ability to modulate the function of a molecule by effecting a structural change upon irradiation with UV light. Find out about our photoswitchable building blocks and their properties.
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The Dawson Linker and its variants provide access to C-terminal peptide thioesters which are crucial components of Native Chemical Ligation reactions. Read on to discover all derivatives available at Iris Biotech!
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We are highly excited to see the research that our products are used for. Send your peer-reviewed scientific publication to publication@iris-biotech.de for citation – we will reward you.
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You want to get an overview about the various resins available at Iris Biotech as well as their specifications, differences, and applications? Read on for further information and details.
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Read on for detailed information on the results of our comparative study on different methods to tackle aspartimide formation. Click here!
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No matter how much you hate them, in the pharmaceutical world you have to deal with them: Impurities. Iris Biotech can provide you with the molecules you require. Click here for more detailed information.
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From mg synthesis of a peptide up to bulk quantities often makes a huge difference in the route of production. Read on for more information about Iris Biotech’s process development services.
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Linkers serve as versatile tools, e.g. during SPPS or for the sophisticated (self-immolative) conjugation of a potent small molecule to a carrier. Check out our selection of over 100 readily available linkers.
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See how our “mRNA grade” DTT and Spermidine can support also your nucleic acid production. Read on for more information.
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Jensen et al. developed two methods that use poly-His sequences to direct the highly selective acylation of proteins, either at the N-terminus or at a specific Lys residue. Read on for more information.
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We can’t get enough of new products and innovations! Read this blog to get detailed information on the cyanylating reagent NTCB as well as selenocysteine amino acids, both useful tools for peptide ligation.
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You missed our workshop featuring Prof. Knud J. Jensen (Professor, Head of Group; University of Copenhagen)? Any further questions? Please get in contact via info@iris-biotech.de.
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Curious about our latest portfolio additions from July to December 2022 and the 2022’s overall product and newsletter highlights? Click here to check out the summary or get in contact for more details!
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(Bi)functional dioxoborolane and disulfide-based self-immolative linkers – mode of action and application examples for the detection of H 2 O 2 , for prodrug design, and reversible peptide cyclization.
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The HaloTag®, SNAP-Tag® and CLIP-Tag TM represent versatile tools for the specific, covalent attachment of in principle any molecule of choice to a protein of interest. Discover our substrates!
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We are pleased to serve as your platform – either to highlight your science performed with our building blocks or to market innovative building blocks you are developing! Read on for more information!
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PEGs are being used as spacers, as hydrophilic decoration, and building blocks. Read on for more detailed information about the reactivity of different PEG derivatives and how to use them.
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From evolution to solution - natural products are an infinite source of (bio)active compounds. In this series we present how natural products can be conjugated to empower their inherent potential.
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Peptide therapeutics – fewer injections/lower doses by prolonging their half-life via addition of a lipid modification that promotes binding to serum proteins such as albumin. Read on for recent innovations!
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Building blocks with a strained triple bond do not require copper catalysis when used in click chemistry. Discover CliCr®: improved solubility in aqueous conditions and high reactivity! Click here!
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Infinite like the deep sea – marine natural products are an infinite source of (bio)active compounds. In this series we present how natural products can be conjugated to empower their inherent potential.
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Shine bright like our fluorophores! Learn how our superior fluorogenic protease substrate peptides can enhance your test performance. Click here to gather more information and discover available products!
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Discover our diazirine-substituted building blocks suitable for the analysis of protein-protein and RNA-protein interactions via proximity labeling upon photoactivation. Read on for more information!
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Allotropes of carbon show distinct characteristics in structure and e.g. electric and biophysiological properties. Discover how these materials can be further exploited by linker attachment!
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Discover the cyanobenzothiazole (CBT) click reaction , a not (yet) so well-known biocompatible and bio-orthogonal mechanism faster than the famous azide-alkyne cycloaddition (CuAAC).
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TCEP is an effective reductant for disulfide bonds and a versatile reagent for various applications in protein science with distinct advantages compared to DTT and BME.
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Bioengineering in combination with Linkerology® . Check out the unique options for membrane proteins, recombinant immunotoxins (RITs) and novel antibody-drug conjugates.
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You want to attach your small molecule to a certain carrier? Let’s analyze the functional groups present and discuss Linkerology® possibilities for permanent or trigger-inducible, tracelessly-cleavable linkage.
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Keeping control! PEGylating reagents with a squaric acid ethyl ester react chemoselectively with side chain amino functions of surface-accessible Lysines in proteins. Other functionalities are not affected.
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A heart of gold! Metals and ores - see here how their surfaces can be equipped with bifunctional organic linker molecules and thus be turned into modifiable biocompatible materials.
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Add glycans to your proteins with our ready-to-use Fmoc asparagine building blocks suitable for solid phase peptide synthesis and produce peptides with exactly defined glycosylation patterns!
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Curious about the highlights of our 2023 portfolio additions? Discover innovative building blocks and latest technologies! Read on to check out the summary or get in contact if you need more details!
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The targeted delivery and traceless release of drugs is an important concept in pharmacology. Discover the possibilities of payload conjugation to carrier proteins shown for the example drug Elacestrant.
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Engineer shape-shifting peptides , controllable by a laser as magic wand! In this newsletter, we’ll explore the possibilities of photo switchable building blocks based on azobenzene.
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You are looking for monodisperse Sarcosines ? You want to use Sarcosine for SPPS? You need to improve your drug's hydrophilicity and search for PEG alternatives? Read on!
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Beyond cysteines: Unlock targeted side-chain modifications of your peptides and proteins via the introduction of 1,2-aminothiols and subsequent click-like functionalization.
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Have an additional ace up your sleeve for selective and efficient peptide modification, cyclization, and/or bioconjugation. Explore 2-cyanopyridines for click-like reactions. Get more information!
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Discover photocages – photosensitive protecting groups that are removed by irradiation with light of a defined wavelength, thus restoring the original, “active” state.
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Level up! Carboxymethyl-modified amino acid building blocks suitable for incorporation by solid-phase peptide synthesis. Learn more about available derivatives and their properties.
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