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Find out more about our partner SciClix from Singapore and our new collaboration!
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The Fmoc group is the most frequently used protecting group in peptide chemistry. The most common deprotection conditions involve a solution of 20% piperidine in DMF.
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PGA (Penicillin G Amidase, Penicillin Acylase, Penicillin Amidohydrolase from E.coli on acrylic resin, Systematic name: Penicillin amidohydrolase, E.C. 3.5.1.11) has an active pocket, which is very specific for phenyl acetic acid. The prominent commercial use is hydrolysis of a phenylacetamid bond during production of the penicillin API 6-APA (De Martin et al., J. Mol. Catal. B:Enzymatic 1999; 6: 437). The high specifity of PGA towards the Phenylacetyl moiety makes the use of Phacm as new alternative ...
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Dendrimers offer a new possibility to derivatize small molecules, surfaces or biopharmaceuticals with a monodisperse macromolecule and alter in this way properties like solubility and hydrophilicity. Immunogenicity and pharmacokinetics of pharmaceuticals will be improved. The synthetic approach for designing these dendrons of different generations is based on 2,2-bis(hydroxymethyl) propionic acid, which is a non-toxic and biocompatible building block.
The size can be designed from 250 g/mole for 1st gene...
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alpha-Sulfo-beta-Alanine has been used to couple to hydrophobic labels like Cyanine and Rhodamine dyes and other hydrophobic residues to increase their solubility in water. As di- or tripeptide a further increase of hydrophilicity can be achieved. Fmoc-beta-Ala(SO3H)-OH can be coupled in SPPS by standard phosphonium or uronium based coupling reagents. In high throughput technologies for DNA sequencing and genomics charge-modified dye-labeled dideoxynucleoside-5’-triphosphates were synthesized for &ls...
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Cleland's reagent, also known as dithiothreitol or DTT is a water soluble protective reagent for sulfhydryl groups. It reduces disulfide linkages to free sulfhydryl groups in proteins and enzymes. It is a component of buffers used in protocols for the isolation and purification of proteins.
DTT (racemic), Cleland's Reagent
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Mal-AMCHC-OSu
trans-N-Succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate
Formula: C 16 H 18 N 2 O 6 Molecular Weight: 334,33 g/mole
CAS: 64987-85-5
CODE: MAA1000
1g: EUR 300,- US$ 420,- 5g: EUR 1200,-  ...
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Properties of the MiDye Chromophore System:
Readily applicable to biolabelling, Click conjugation protocols and peptide synthesis
Stable under buffer conditions (pH 4-8) and in solid phase peptide synthesis
Broadly applied in cell und animal imaging, tested in FRET systems
Available in larger quantities compared to e.g. Alexa, Cy-Dyes etc.
Purities > 85%, supplied as freeze-dried solid powder
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3rd Modern Solid Phase Peptide Synthesis & Its Applications Symposium
Daydream Island Resort, The Whitsundays, Queensland, Australia, 13-16 October 2011( www.spps2011.org )
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Building Blocks for the synthesis of 2,3-diaminobutanoic acid containing peptides or for Click reactions.
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DTNB, frequently called Ellman’s Reagent, used as reagent for determination of free sulfhydryl groups.
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Resin especially designed for the synthesis of long and difficult peptide sequences!
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June 18th-19th, 2013 Newmarket Racecourse Conference Centre, Cambridge, UK
This 2-day conference and exhibition will feature top-level papers from industry and academia enabling delegates to learn how they can improve their research and development in the areas of peptide discovery, development, manufacture and application.
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Aryl azides are well-known precursors of nitrenes and have been introduced by Fleet et al . as versatile photoaffinity labeling agents to probe biological receptors.
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March 10th-13th, 2014 Suntec Convention & Exhibition Centre Singapore
The BioPharma Asia Convention is the leading industry platform for pharma, biotech, CROs, CMOs, research institutes, investors and industry stakeholders to network and discuss the latest industry trends, partnership models and investment opportunities in Asia.
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A set of new statin analogues, so called Super-Threonines, is available consisting of Fmoc protected L-enantiomers with all possible 4 stereoisomers of chiral centers in the side chain. They appear in nature as bridge building element in cyclodepsipeptides, like pipecolidepsin A, a compound which shows relevant cytotoxic activity in three human tumor cell lines (lung, colon, breast) and has unique structural features.
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Bis Thiol & Amine reactive PEGylated Cross-Linker which has been used for enhanced receptor binding, for the design of long-acting conjugates for type 2 diabetes therapeutics and in reorienting the Fab Domains of Trastuzumab Results in Potent HER2 Activators.
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April 1st - 4th, 2014 Messe München Germany
For four decades, analytica has been the leading international fair for state-of-the-art laboratory technology and pioneering biotechnology . No other trade fair in the world covers the range of subjects to do with the laboratory in industry and science in such breadth and depth, and on such a scale.
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Superior Performance at a Sensational Price!
Available as –COOH, -NHS, -Maleimide, -Alkyne, -Azide
Half the price of other well-known dyes like Alexa- & Cy-Dyes.
Available also in large quantities.
Broadly applied in cell imaging, FRET, fluorescence quenching.
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Phthalimidooxy PEG-based cross linkers form stable oximes with aldehydes, also latent ones as present in carbohydrates. Their reactivity is sufficiently mild for a broad used in creating conjugates with sensitive biologics.
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Tyramine compounds are converted to highly reactive radicals by horseradish peroxidase in presence of H2O2 which preferentially react with surface exposed tyrosines. Biotin Tyramide and Biotin-PEG-Tyramide therefore are ideal reagents used for tyrosine-/protein-biotinylation.
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May 19th - 21th, 2014 Centro de Investigación Príncipe Felipe Valencia, Spain
Unlike other Drug Delivery Symposia that have a broader remit, this unique conference series was specifically established to provide a forum for interdisciplinary exchange of state-of-the-art techniques and advances in knowledge relating to the design, clinical development and commercialisation of Polymer Therapeutics.
The key topics discussed during the 10th International Symposium on Polymer Therapeutics are...
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July 2nd - 4th, 2014 Rouen’s Law Faculty Rouen, Normandy, France
The “Golden Jubilee” of the “Rencontres Internationales de Chimie Thérapeutique” (RICT) will focus on “Interfacing Chemical Biology and Drug Discovery” . Chemical Biology can be defined as the use of chemical tools to unravel biological processes. The chemical approach to Biology may not only contribute a quantitative framework for the description (and prediction!) of complex biological ev...
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Benzotriazol activated carboxylic acids:
Fast reaction (within minutes) at room temperature with amines and other nucleophiles under addition of base (in both water and non- aqueous solvents).
Stable to racemization when coupling with nucleophiles.
High solubility in organic solvents like DMF and DCM.
Stable in water.
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Used for Efficient and Economic Bulk Synthesis of Peptide APIs:
A new technology is available with a set of new preloaded resins, which enable the synthesis of peptide amides WITHOUT ANY LINKER. Amino acid amides, which bear a functional side chain, are immobilized on acid sensitive resins. This makes process development, small scale synthesis, bulk production and in-process control very easy.
Find more technical details in our application for demonstration purposes with BIVALIRUDIN.
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Novel liposomes built of dPEG-Phospholipids with defined PEG chain length provide prolonged blood-circulation time and improved cellular uptake as administration carriers for drugs, delivering active molecules to the desired target.
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In modern biotechnology there are numerous applications for the luminogenic luciferase assay. We supply luciferin from mg scale for research applications like monitoring of gene expression or tumor growth up to kg quantities for hygiene surveillance in food industry
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GABA is a neurotransmitter in the central nervous system of mammals and its deficiency is associated with severe neurological disorders. Statine, a GABA analogue, occurs in several peptide APIs.
Derivatives of gamma-amino acid analogues are of continued vital interest for a variety of applications in medicinal chemistry. We have a tool box available to offer a broad range of substituted gamma-amino acids and statines on custom synthesis basis.
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The presence of catalytic copper, limits the in vivo application of the Click this reaction for several reasons.
We offer custom synthesis of Strained Cyclooctynes and Substituted 1,2,4,5- Tetrazines as building blocks for fast Click reactions in the absence of any catalyst.
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1,4-substituted 1,2,3-triazole are isosteric to peptide bonds and result in peptide mimetics which even retain activity e.g. in case of certain tyrosinease inhibitors.
We offer custom synthesis of Alkyne Amino Acid Analogues as building blocks for triazol formation via Click conjugation. Side chains can represent all natural amino acids or unusual residues. In combination with our alpha-azido acids we can offer the whole range of building blocks to design Click-peptide bond analogues for every proteinoge...
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September 22nd - 24th, 2014 St. Julien Hotel & Spa Boulder, CO USA
ABOUT THE BOULDER PEPTIDE SYMPOSIUM The Boulder Peptide Symposium seeks to bring together key decision leaders from both industry and academia to discuss the future of peptide therapeutics. Peptide therapeutics are potent and highly selective yet their development into effective treatments can be challenged by limited delivery routes, product stability, manufacturing challenges and an evolving regulatory landscape. BPS is the ke...
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October 7th - 9th, 2014 Paris Nord Villepint Paris, France
Join us in Paris for CPhI Worldwide 2014 , the world's leading pharmaceutical networking event, co-located with ICSE, P-MEC and InnoPack.
CPhI Worldwide hosts 2,500 exhibitors and 35,000 attendees from 140 countries.
Meet face-to-face with international pharmaceutical companies, stay informed about the latest industry trends and remain one step ahead of a constantly changing pharmaceutical market.
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In the era of internet a printed edition of a catalogue still has some advantages and fans. You can make handwritten notes in your catalogue. The overview at each page inspires you to think about structure diversity or alternative strategies in terms of protecting groups, coupling reagents or immobilization. You quickly see what is commercially available and get fast an impression about approximate costs of your synthesis.
Order now online >
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For introducing amino-PEG-acids into a peptide chain, several affordable building blocks are available with all conventional protecting groups. They can be incorporated at any sequence position by standard coupling protocols.
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Positions next to Glycine are often reasons for side reactions, as aspartamide or diketopiperazine formation can occur. Dmb and Tmb can be used for temporary protection of the amide nitrogen of a peptide bond, in order to solubilize the peptide and increase yield and purity.
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Fatty Acids for Click Conjugation
Fatty acid residues and alkyl chains in general can improve solubility and anchoring in membranes and other Lipophilie environments. Find a selection of promptly available short and long chain clickable acids in our web store. Any other – including functional groups for copper-free Click conjugation can be made on custom synthesis basis.
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alpha-Sulfo-beta-Alanine has been used to couple to hydrophobic molecules and peptides and increase solubility. Attachment can be carried out by conventional Fmoc/tBu protocols.
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Fmoc-Sieber amide resin is an acid-labile carrier for solid phase synthesis of peptide amides. Cleavage with only 1% TFA makes it an ideal carrier for the synthesis of protected peptide fragments in fragment condensation strategies for the synthesis of long peptides.
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Pseudoprolines derived from Serine and Threonine have developed to standard building blocks for peptide synthesis since their invention. Now this technology is also available with Cysteine residues, as the corresponding 2,4-dimethoxyphenyl-pseudothiaproline is compatible with standard Fmoc/tBu protocols.
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We at Iris Biotech, are pleased to announce that we have entered into an agreement with Peptide Solutions, LLC to sell the complete line of our products in the USA and Canada.
Peptide Solutions’ website has a link to our complete list of products so ordering online is extremely easy, however, personal contact is available at the phone listed above, Monday through Friday, 8am to 5pm MST.
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Alkylating the Nitrogen of an amide bond results in peptoid structures, leading to conformational restrains, like N-methylation and allows backbone derivatisation. Applications already have been published with Cilengitide, Piscidin 1, and MC4 receptor agonist.
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Oligo-glycines are either flexible linkers or form well defined rigid substructures. We offer a variety of oligo-glycines as building blocks which can easily be introduced into any molecule.
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Visit our Glycine section and find a series of amino acid derivatives, where oxazole is the characteristic structural element carrying carboxy and amino function.
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Surprising behavior of NXO-peptides.
It is a significant property of peptides that oxalo-retro azapeptides have the same donor and acceptor distances and properties for hydrogen bridge formation as a tripeptide fragment and therefore induce beta-sheet formation at this position.
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October 13th - 15th, 2015 Feria de Madrid, Spain
Join us in Paris for CPhI Worldwide 2015 , the world's leading pharmaceutical networking event, co-located with ICSE, P-MEC and InnoPack.
CPhI Worldwide hosts 2,500 exhibitors and 35,000 attendees from 140 countries.
Meet face-to-face with international pharmaceutical companies, stay informed about the latest industry trends and remain one step ahead of a constantly changing pharmaceutical market.
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October 22 to 25, 2015 Ramada Couran Cove Island Resort, South Stradbroke Island, Queensland, Australia http://solidphase.org
The symposium provides a superb opportunity for all practitioners of solid phase peptide synthesis together with those who use synthetic peptides for a myriad of applications to congregate at the beautiful Couran Cove Resort, South Stradbroke Island, a short ferry ride from the famed Gold Coast of Queensland .
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Peptide linkers usually are cleaved under acidic conditions or using two-step procedures. Photocleavage proceeds under neutral conditions using UV light and can either be performed in batch or using flow chemistry.
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Click chemistry is a convenient method to chemoselectively functionalize peptides at specific positions. We offer a variety of different propargyl amino acids for both Fmoc and Boc strategies, for enzymatic synthesis, as well as preloaded resins for SPPS.
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We now offer N,N' -Bis-Boc- N" -triflylguanidine , at both a very competitive price and our habitual high quality. Find out about the usefulness of this and our other guanylation reagents!
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2-Furyl-alanine can be incorporated into peptides via SPPS or by using enzymatic approaches. UV-irradiation in the presence of oxygen and a photosensitizer converts furyl-alanine to an intermediate that selectively reacts with certain nucleophiles. This property can be employed for site-specific labeling of peptides and proteins.
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Our new Biotin-SS-Tyramide linker is a valuable tool for peroxidase-promoted targeted protein biotinylation. By using peroxidase-tagged antibodies, proteins and protein clusters can be selectively biotinylated, and then isolated using streptavidin. The biotin tag can be subsequently removed using reducing agents (e.g. glutathione).
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The Fmoc-L-Phe-Aca pseudo-dipeptide is a useful reporter group for the successful internalization of CPPs. Phe quenches the fluorescence of Aca. Internalization of the peptide containing Phe-Aca leads to proteolytic cleavage of the Phe-Aca bond and thus to fluorescence.
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Polytriazole ligands such as THPTA accelerate the copper-catalyzed azide-alkyne cycloaddition (CuAAC), or “Click”, reaction. Moreover, with the use of further additives, polytriazoles facilitate CuAAC even in live cells by significantly lowering the bioavailability of the copper catalyst.
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The reaction between a tetrazine (Tz) and a trans -cyclooctene (TCO) is the innovative third generation Click reaction that proceeds without the use of copper or other catalyst. It is rapid, fully bioorthogonal and excels at very low concentrations.
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Peptides as pharmaceutical compounds suffer from unfavorable pharmacokinetics which is, among other things, due to a slow uptake into cells and rapid proteolytic cleavage. N -Alkylation of peptides is a valuable tool to overcome these limitations. We now offer new kits that enable the facile preparation of peptoids and N -alkylated peptides.
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The regioselective formation of multiple disulfide bonds is often a synthetic challenge. We now offer an innovative safety-catch Cys protecting group that allows selective deprotection of the sulfhydryl group and is a valuable addition to the peptide chemist’s toolbox.
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The SCAL linker offers superior chemical stability and permits a variety of orthogonal solid-phase approaches. It is fully compatible with the Fmoc-, Boc- and Alloc- strategies. Cleavage can be performed either by a simultaneous, or by a two-step reduction/acidolysis procedure to afford peptide amides.
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Omniligase-1 enables efficient and racemization-free ligation of two side-chain unprotected peptide fragments at many different positions. Test this innovative enzyme developed by EnzyPep B.V. using the complementary model peptides included in our kit!
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The classic FRET pair EDANS and DABCYL is now available linked to Fmoc amino acid building blocks that can be readily used in SPPS. Conveniently synthesize your own custom protease substrates!
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This innovative auxiliary facilitates Native Chemical Ligation at the position of a Glycine residue in a peptide sequence. The auxiliary can be further functionalized, e.g. by PEGylation. Following NCL, the auxiliary is removed by irradiation with UV light.
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4-6 October 2016 Fira de Barcelona Gran Via, Barcelona Spain
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10-13 October 2016 San Diego, CA, USA Marriot Marquis & Marina
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Conjugates of PEG and folic acid or cholesterol, respectively, combine the positive properties of these molecules. Those conjugates are available with a wide variety of functional groups and different PEG chain lengths to suit your needs.
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Fmoc-L-Dap(2-Boc-aminoethyl)-OH is the first in a series of new triamino acid building blocks. This azalysine is useful for introducing positive charges into a peptide, or for creating branched structures.
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In this news section, we highlight three useful coupling reagents for peptide chemistry: PyCLOCK, PyAOP and HDMA.
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We now offer a series of Lysine dendrons for chemoselective functionalization of molecules containing carbonyl groups. These multivalent molecules carry diverse types of moieties, such as amine- or hydroxyl-groups, DOTA chelators or triphenylphosphonium (TPP) cations.
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Amino acids of high quality are crucial for the synthesis of peptides with a high purity.
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Polylysines are polymers of the canonical amino acid Lysine, and are characterized by their high charge density caused by the presence of one free amino group per lysine monomer.
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Poly-(α-L-glutamic acid) is a synthetic polypeptide of L-Glu linked by the alpha-amino groups (α-PGA). These polyanionic and biodegradable polymers can be used for a variety of purposes.
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May 7-10, 2018
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Iris Biotech introduces a comprehensive set of photo-crosslinking amino acids bearing the diazirine moiety.
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The 2D monolayer cell culture model is widely applied for drug screening. However, this approach is frequently not able to adequately mimic the in vivo response.
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Indocyanine Green (ICG) dye, a material approved by the FDA for various applications, is a powerful tool for imaging in live cells and tissues .
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Protease inhibitors are molecules that inhibit protease function by binding either reversibly or irreversibly to the enzyme.
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The Allocam protecting group allows for selective deprotection and disulfide bond formation on-resin in one step.
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5 - 7 September 2019
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21 - 22 October 2019
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12 - 15 November 2019
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5 - 7 November 2019
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Wir freuen uns Ihnen unsere drei neuen Teammitglieder vorstellen zu dürfen:
Frau Lusine Davtyan (li.) absolviert bei der Cfm Oskar Tropitzsch GmbH ein 6 monatiges Praktikum im Bereich Gesundheitsmanagement.
Frau Celine Pohlers (mi.) begann eine Ausbildung bei der Cfm Oskar Tropitzsch GmbH als Kauffrau Groß- und Aussenhandel, Fachrichtung Aussenhandel.
Frau Sina Weichold (re.) begann die selbe Ausbildung bei der Iris Biotech GmbH.
Wir wünschen unseren jungen Mitarbeiterinnen viel Freude bei ...
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Proximity labeling of proteins with biotin-phenol (biotin-tyramide) and an engineered peroxidase enzyme (e.g. APEX = Engineered Ascorbate Peroxidase) is a pivotal tool for molecular biology.
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Biotinylation of proteins and their purification via Streptavidin beads is a widely applied method.
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27 - 29 January 2020
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Betulin and its derivatives are pentacyclic triterpenoids of the lupane-type. They are natural products that occur as secondary metabolites in over 200 different plants. Betulinic acid (BA) is a derivative of betulin that is oxidized at C-28.
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The presence of phenyl groups in APIs is connected with various disadvantages. An increasingly popular solution is the use of BCP as a phenyl ring bioisostere. Find out more about this highly diversifiable motif.
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Peptide purification after SPPS usually requires time- and solvent-consuming HPLC, which is often limited by co-eluting side-products. Belyntic’s catch-and-release PEC-Linker chemoselectively catches the desired product from your crude to reach a new dimension of purity.
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Sidechain-derivatized amino acids have shown great potential in enhancing select properties of peptide lead compounds. Find the most recent additions to our portfolio of amino acids bearing additional aryl and alkyl groups in their side chains.
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DTT is a powerful yet mild reducing agent. Based on your demand we can offer different quality grades to suit your needs.
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Alkyne amino acids allow for Click conjugations and other types of chemistry. Read more about alkyne-functionalized amino acids and our related products.
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Now in India available: the Belyntic Kits Peptide Easy Clean (PEC)
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The ever-growing sophistication and variation in linker design have given rise to a new and distinct field of knowledge in synthetic chemistry termed Linkerology. Discover our expertise and panoply of new cutting-edge tailor-made linker constructs for the latest state-of-the-art bioconjugations.
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Placing Dde as one terminal group of a linker and a functional group prone for conjugation as the other or using Dde as the central connective portion of a linker, allows for the creation of new bifunctional linkers.
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Amongst various somatostatin analogues, the pentacyclic heptapeptide TT-232 bears unique properties. Iris Biotech offers TT-232 as triacetate and trifluoroacetate salt, respectively, as well as conjugated to either biotin or the fluorophore indocyanine green.
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Learn, how His-Tag can be used for specific linker attachment. Another example in our LINKEROLOGY series of sophisticated linker technologies.
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Looking to optimize or functionalize your peptide? Explore our ever-growing selection of Arg derivatives and find the one suitable for your application.
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Iris Biotech presents the next-generation of hydrolysis-stable phosphono-analogs of pSer, pThr and pTyr. Fluorination renders the phosphonic acid more acidic and thus an even better mimic of the parent phosphoamino acid.
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Iris Biotech presents (functionalized) fullerenes of different core size (C60 vs. C70) as versatile tools for multiple functionalization. Read more about their unique properties and fields of applications.
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Nitrodibenzofuran (NDBF) is a photocleavable side chain protecting group that can be removed by photolysis upon irradiation with UV-light or – especially for in vivo applications – by two-photon excitation using near infrared light.
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The variations for linkers are endless, as in our catalogue program already hundreds of different derivatives are available for conjugation of small molecules, biomolecules and surfaces to each other.
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Trypsin (EC 3.4.21.4), an endopeptidase and natural protease found in the digestive system, cleaves peptide chains and proteins predominantly at the carboxyl side of the amino acids Lys and Arg (except when followed by Pro).
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Click Chemistry in DNA Synthesis - Applications and Procedures in DNA Synthesis
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Protein and lipid glycosilation is a life-governing and omnipresent process. Glycoconjugates display a multitude of biological effects from protein folding and stabilization, energy storage, cell surface interaction through molecular recognition motifs for cell-cell communication, and structural support and protection.
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The azido group can be reduced to an amino function and hereby serve as masked amino group. It is of particular use if additional orthogonalities are needed. Azido is stable towards treatment with piperidine (Fmoc deprotection), Pd(0) (Alloc removal) and acidic treatmet (cleavage of Mtt, Trt or other acid sensitive groups). However, as it is a pseudohalogenide, care has to be taken during coupling steps, as HATU will cause high racemization. This can be avoided using collidine or other non-nucleophilic bas...
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Mutant or modified aminoacyl tRNA synthetases (aaRS) have been used to charge non-natural amino acids to the corresponding tRNA, which incorporates them into polypeptides or proteins during recombinant synthesis.
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a) Catalyst-free Click Reaction
Cycloaddition reactions such as the [3+2] azide-alkyne and the [4+2] Diels-Alder reaction, are becoming common conjugation techniques. Applications range from imaging, drug design and development of sensors, thereby spanning the fields of chemical biology, material science, surface and polymer chemistry as well as many other fields.
Introduced in 2002, the copper-catalyzed variant of the azide-alkyne cycloaddition (CuAAC) reaction has found broad applicability in t...
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Azido and alkyne functions can cyclise by an intramolecular CuI or Cu0 catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC). This so-called Click Reaction, developed by K. Barry Sharpless and Morton Meldal, has meanwhile grown to a widely used type of reaction orthogonal to many other types of reactions in different kinds of applications.
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Mercapto-PEG-Acids are highly hydrophilic, non-antigenic, non-immunogenic and non-toxic.
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Nanotechnology and nanobiotechnology using gold or silver particles, quantum dots or even magnetic particles are broadly diverse, rapidly expanding areas of study in medical diagnostics and therapeutics, sensoric and chemistry.
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Amino protected amino-PEG-acids can be used for the PEGylation of solid particles in order to create hydrophilic and reactive surfaces with no non-specific binding issues.
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PEGs show a spectrum of unique physical and chemical properties, which have been described in literature extensively by the pioneers in PEGylation: Harris, Veronese and recently by Hermanson. Here are summarized the most common known properties.
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Potential alternatives to PEGs, polypeptoids in general and polysarcosine (PSR) in particular stand out in terms of safety, synthetic control and versatility.
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Polyglutamates are well known to be highly biocompatible, biodegradable and multifunctional polymers, which have already been used as building blocks in polymer drug conjugates and polymeric micelles.
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The polymers in this context are a polymeric linear structures with n repeating units of monomers. Depending whether the polymer is consisting of one single molecular weight (only one n existing) or of a range of compounds with an average mass and a distribution of n around a mean value, polymers are referred to as “monodisperse” or “polydisperse”.
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Small drug molecules and also large biomolecules like proteins or antibodies suffer rapid clearance from human body.
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Abstract: An easy and efficient solid-phase synthesis strategy to obtain rapidly water-soluble chromophores/fluorophores in highly pure form has been developed.
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Abstract: N alpha-9-Fluorenylmethoxycarbonyl-N epsilon-4=methyltrityl-lysine, [Fmoc-Lys(Mtt)-OH], was prepared in two steps from lysine, in 42% overall yield.
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Abstract: A symposium report. Protected peptides were synthesized using 9-fluorenylmethoxycarbonyl (Fmoc) amino acids and the acid labile 2-chlorotrityl and the multidetachable 2-chlorotrityl-Rink-linker resins.
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Abstract: A considerable number of biologically active naturally occurring products are peptides, depsipeptides, and peptide conjugates.
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Ulf Hanefeld, Lucia Gardossi and Edmond Magner
Chem. Soc. Rev. 2009; 38 :453–468; https://doi.org/10.1039/b711564b
Abstract:Enzymes are versatile catalysts in the laboratory and on an industrial scale. To broaden their applicability in the laboratory and to ensure their (re)use in manufacturing the stability of enzymes can often require improvement. Immobilisation can address the issue of enzymatic instability. Immobilisation can also help to enable the employment of enzymes in differe...
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Chiara Carboni, Hans G. T. Kierkels, Lucia Gardossi, Kamil Tamiola, Dick B. Janssen and Peter J. L. M. Quaedflieg
Tetrahedron Asymmetry: 2006; 17 : 245–251 https://doi.org/10.1016/j.tetasy.2005.12.023
Abstract: We have demonstrated for the first time that D-glutamine (D-Gln) and D-glutamic acid (D-Glu) can be efficiently obtained in high ee (97% and 90%, respectively) by enzymatic kinetic resolution of D,L-Gln and D,L-Glu. This was achieved by enantioselective conversion of...
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Interested in histidine derivatives? Iris Biotech provides a selection of deamino- and decarboxy-products. Find out more about benefits and potential applications of our new building blocks.
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Mercapto acids were attached through their thiol group onto 2-chlorotrityl (Clt)-, trityl (Trt)-, 4-methyltrityl (Mtt)-, 4-methoxytrityl (Mmt)-, and 4,4'-dimethoxytrityl (Dmt)-resins.
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Peptides are key to modern drug discovery. This article reviews the requirements for bulk production of peptides and how it affects research and production of smaller scales.
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T. M. Postma, M. Gongora-Benitez, J. Tulla-Puche, U. Giesecke, T. Bruckdorfer, F. Albericio
Conference Paper: 23rd American Peptide Symposium 2013
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A novel, ethylene glycol-based protecting group is designed and synthesized for use in solid phase peptide synthesis.
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One approach for the design of bioactive peptides with improved pharmacological properties is the derivatization of amino acid building blocks with fluorine. Find out more about the advantages of fluorinated peptides.
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Methionine is particularly prone to oxidation by atmospheric oxygen in vitro but also by reactive oxygen species in vivo, resulting in the corresponding sulfoxide and sulfone. Read on to find out more.
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Enzymatically-activatable probes based on 7-amino-4-methylcoumarin (AMC) represent versatile tools for the detection and localization of proteolytic enzyme activities. Read on to find out more.
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Interested in the formation of peptide thioesters for Native Chemical Ligation? Read on to find out more about the use of Dawson Linker derivatives as thioester surrogates compatible with Fmoc SPPS.
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The linkage of a drug to its carrier via a disulfide-based self-immolative linker allows for the specific intracellular release of the active molecule upon glutathione reduction and linker cleavage.
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The sterical interference of three closely positioned methyl groups favors amide cleavage and payload release upon lactonization. This cascade can be induced by various triggers. Read on to find out more.
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The new disulfide-based protecting group sec-isoamyl mercaptan (SIT) is fully compatible with Fmoc- and Boc-SPPS and can easily be removed reductively upon addition of dithiothreitol.
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Cyclopropanes represent important design elements in medicinal chemistry and are widely present in drug compounds. Read on to find out more about their full potential.
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Frustrated by aspartimide formation during peptide synthesis? Iris Biotech presents aspartate derivatives with bulky side chain protecting groups that minimize the formation of aspartimide-related side-products.
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Herein we present two arginine derivatives, in which the native guanidino group is replaced by an isosteric amino-functionalized carbamoylated guanidino group that can serve as an attachment point for further derivatization.
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An efficient, versatile linker developed for the synthesis of C-terminal primary/secondary amides and hydrazides as well as peptide alcohols, which is compatible with SPPS and suppresses side reactions.
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The highly lipophilic, bulky adamantyl motif is a promising and validated building block to increase the drug-qualities of lead compounds without increasing their toxicity.
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Fmoc-Asp(CSY)-OH – an innovative building block to suppress aspartimide formation during peptide synthesis by utilizing cyanosulfurylide as carboxylic acid protecting group. Read on to find our more!
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Are you using the Fmoc-MeDbz-OH Dawson Linker in large scale on a regular basis? A robust and economic processallows us to promptly provide you with kg quantities at competitive prices and in high quality.
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Interested in structure activity studies on your Arginine containing peptide or further optimization for improved receptor binding? Explore our guanidino Proline derivatives as rigid Arginine mimics.
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Cys(Aapam): an Alloc protected Phacm linker as removable side chain modification for the incorporation of e.g. solubilizing tags facilitating the preparation of hydrophobic peptides and proteins.
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Interested in studying the effect of palmitoylation on your peptide’s localization, function, and stability? Read on to find out more about the use of lipidated “fatty” amino acids!
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Read on to find out more about Iris Biotech’s Linkerology® portfolio including substituted pyridyldithiols as building blocks for the reversible chemical conjugation to sulfhydryls.
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Iris Biotech offers hetero-bifunctional crosslinkers bearing an N-hydroxysuccinimide (NHS) ester and a maleimide group suitable for the reaction with amine- and thiol-containing molecules.
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Serine- and Threonine-derived oxazolidines as well as Cysteine-derived thiazolidines, so-called Pseudoprolines, serve as structure-disrupting, solubilizing building blocks in peptide synthesis.
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Iris Biotech offers various (protected) azide- and alkyne-modified fatty acid derivatives suitable for Click Chemistry. Interested? Read on to find out more!
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Interested in structure-activity studies of your Proline-containing peptide drug? Find out more about the use of Methanoprolines and Dimethylprolines as conformational amide locks.
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The incorporation of alpha-trifluoromethyl substituted amino acids into peptides increases proteolytic stability, enhances lipophilicity, and induces secondary structures. Read on to find out more!
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The peptide-based ADC linkers Val-Cit and Val-Ala are efficiently cleaved by lysosomal proteases and benefit from increased serum stability and effective payload-release in targeted cells.
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Compounds of the shown formula can simply be bound to solid supports via amide bond formation without racemization of the C-terminal amino acid and enable the synthesis of very pure peptides.
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Herein, we present Fmoc-protected N-alkyl-substituted carboxy linkers, which can be elongated by Fmoc-SPPS and can easily be linked to amino-functionalized solid supports. Read on to find out more about their advantages.
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Iris Biotech offers a variety of (functionalized) biotin and desthiobiotin reagents reactive towards certain functional groups. Discover our growing portfolio and latest additions.
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Aspartimide formation remains one major hurdle during peptide synthesis. Read on to find out more about different strategies and available products at Iris Biotech in order to avoid this side product.
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Read on for more information about the right handling of Maillard Reaction Products (MRPs), which are frequently used as analytical standards related to food quality and disease processes.
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Selenocysteine (Sec) plays a crucial role for various biological processes, and selenoproteins can be found in all lineages of life. Read on to discover the 21 st amino acid, its derivatives and applications.
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You missed our workshop featuring Prof. Dr. Jeffrey W. Bode (ETH Zurich)? Any further questions? Please get in contact via info@iris-biotech.de
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Discover the versatile applications of hydrazone resins e.g. for the preparation of peptide hydrazides, or the generation of peptide thio esters. Read on to find out more and see our available products.
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Polysarcosines (PSars) – a true alternative to polyethyleneglycols (PEGs) - stand out in terms of safety, synthetic control, and versatility. Interested? Read on to find out more about their properties.
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Discover our selection of Halo ligands as haloalkane dehalogenase substrates, bearing different terminal functional groups suitable for further conjugation, e.g. via Click chemistry.
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Check out our growing portfolio on adamantyl-substituted amino acids and building blocks. At Iris Biotech, we are constantly striving to improve our services, our products, and the routes of synthesis.
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Typically known and employed as preformed dipeptides, we are presenting Serine- and Threonine-derived Pseudoproline monomers as building blocks for solid-phase peptide synthesis.
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Herein we are reporting on the linker stability of amino-PEG-acids achieved via N-methylation and the possible side-reaction without this additional modification. Read on to find out more!
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With a remarkable amount of peptide therapeutics already on the market and many more to come, there is an ongoing need to improve manufacturing scale and efficiency for a sustainable, global supply.
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Common protocols for the loading of 2-CTC and MBH-Br resins presume the application of DCM, THF, or DMF; these solvents are considered as undesirable in accordance with modern regulatory rules.
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See a summary of our advent calendar surprises and benefit from special discounts and great offers! Interested? Just click here to check-out all available products.
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Herein, we summarize certain product highlights and innovations, which we presented in our newsletters 2021. Have a look and get in contact for more information or an individualized offer.
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Discover our selection of substrates for Halo-, Snap-, and Clip-tagged proteins bearing different terminal groups suitable for further functionalization, e.g. biotinylation and Click chemistry.
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Looking for an acid stable protecting group? Struggling with undesired loss of the Cbz protecting group while removing Boc under acidic conditions? Read on to find out more about iNoc as alternative.
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Discover our selection of propargyl-substituted amino acids and find the best position for subsequent Click chemistry within your peptide/protein. Just click here for further information on our products.
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Herein, we present building blocks for the synthesis of protected hydroxylamine derivatives which can be further used for bio-conjugation and various other applications. Read on to find out more!
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Interested in the introduction of Sarcosine (N-methylglycine), e.g. for hydrophilicity increase of your derivative of choice or for PEG replacement? Check-out our available Sarcosine building blocks!
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Interested in polymers for the delivery of promising drug candidates, e.g. nucleic acids? Discover our selection of lipidated polyamino acids and custom capabilities. Read on to find out more!
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Oxidation is not only a known degradation pathway of proteins and peptides in vivo but is also a major side reaction for certain amino acids during peptide synthesis in vitro. Read on to discover our available building blocks.
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We are providing variously functionalized, protected and unprotected fatty acid derivatives suitable for SPPS and further conjugation, e.g. via Click chemistry. Read on to discover our portfolio.
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Iris Biotech offers the main building blocks for the synthesis of Liraglutide and Semaglutide and commonly observed impurities as well as reference standards. Read on for more information!
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Drug the undruggable – click here to get more information about the use of PROteolysis TArgeting Chimeras (PROTACs®) as a tool for targeted protein degradation and discover available building blocks.
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Iris Biotech is your trusted partner in the world of peptides and all related disciplines. Your project requires a compound not listed in our portfolio? Get in contact and inquire for a custom synthesis!
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Replace undesired solvents such as DCM, THF and DMF during the loading of 2-CTC and 4-MBH-Br resin by a “greener” EtOAc/MeCN (1:1) mixture. Click here and read on for more details.
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We want to support you in the development of next generation peptide pharmaceuticals, therapeutics, and diagnostics by easing the process of peptide manufacturing. Read on to gather more information.
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Dyes and fluorescent labels are an invaluable tool for diagnostics, medical and biochemical research. Iris Biotech offers labels with excitation ranges from UV to near-IR and various functional groups.
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You missed our workshop featuring Prof. María Jesus Vicent Docón (Head of Polymer Therapeutics Lab)? Any further questions? Please get in contact via info@iris-biotech.de.
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Photoswitches grant the ability to modulate the function of a molecule by effecting a structural change upon irradiation with UV light. Find out about our photoswitchable building blocks and their properties.
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Are you active in the field of antibody drug conjugates? Click here to find out more about our selection of as well as the technology behind pH-sensitive self-immolative linkers.
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The Dawson Linker and its variants provide access to C-terminal peptide thioesters which are crucial components of Native Chemical Ligation reactions. Read on to discover all derivatives available at Iris Biotech!
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Herein, we present 2-Iminobiotin, a cyclic guanidino analogue of biotin with pH-dependent affinity for avidin, and compare it to biotin and desthiobiotin. Click here for more detailed information.
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You just started working in the field of solid phase (peptide) synthesis and want to get familiar with resins? Click here to get an overview about the different parameters describing resins.
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You want to get an overview about the various resins available at Iris Biotech as well as their specifications, differences, and applications? Read on for further information and details.
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Herein, we present the Clean Peptide Technology using Smoc Amino Acids developed by Sulfotools in Germany. Replace organic solvents with water during peptide synthesis - Read on for more information!
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Herein, we report the first-time SPPS of a special peptide sequence via employment of of a serine pseudoproline building block as well as sec-isamyl mercaptan (SIT) as cysteine protecting group.
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As the molecular diversity of cyclic and branched peptides becomes more and more challenging, a high level of orthogonal dimensionality is required. Herein, we present a new category of orthogonal protecting groups.
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Read on for detailed information on the results of our comparative study on different methods to tackle aspartimide formation. Click here!
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No matter how much you hate them, in the pharmaceutical world you have to deal with them: Impurities. Iris Biotech can provide you with the molecules you require. Click here for more detailed information.
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1,4-Benzenedimethanethiol is used as thiol scavenger during solid-phase peptide synthesis. In comparison to other thiol scavengers, this reagent is odorless and provides high quality crude peptides.
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From mg synthesis of a peptide up to bulk quantities often makes a huge difference in the route of production. Read on for more information about Iris Biotech’s process development services.
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You missed our workshop featuring Dr.-Ing. Sascha Knauer and Dr.-Ing. Christina Uth (Managing Directors; Sulfotools)? Any further questions? Please get in contact via info@iris-biotech.de.
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You are working on complex peptides and are looking for a new level of orthogonality facilitating the overall synthetic process and improving your yields? Check out the Msbh safety-catch protecting group!
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The ChemMatrix® resin production and distribution was discontinued by its manufacturer SEQENS. Products are only available at Iris till current stock is sold out. Read on for more information!
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The 2022 Chemistry Nobel prize is awarded to B. Sharpless, M. Meldal and C. Bertozzi for their work in the field of Click Chemistry. At Iris, we are providing clickable building blocks for nobel chemistry. Read on for more information!
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Linkers serve as versatile tools, e.g. during SPPS or for the sophisticated (self-immolative) conjugation of a potent small molecule to a carrier. Check out our selection of over 100 readily available linkers.
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See how our “mRNA grade” DTT and Spermidine can support also your nucleic acid production. Read on for more information.
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We can’t get enough of new products and innovations! Read this blog to get detailed information on the cyanylating reagent NTCB as well as selenocysteine amino acids, both useful tools for peptide ligation.
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Herein we investigate the incorporation of the Fmoc-Thr-pseudoproline monomer during Fmoc SPPS. Typically, pseudoprolines are incorporated as preformed dipeptides. However, the possibility of using the monomer adds flexibility to the synthesis.
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Curious about our latest portfolio additions from July to December 2022 and the 2022’s overall product and newsletter highlights? Click here to check out the summary or get in contact for more details!
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In two joint studies together with Prof. F. Albericio we investigated the coupling efficiencies of Ser and Thr pseudoproline monomers and their use for the synthesis of inaccessible peptide sequenes. Read on!
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You want to get an overview about the different Click technologies as well as available derivatives and applications? Let’s arrange a (virtual) talk by Iris Biotech about your topic of choice – Contact us!
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The HaloTag®, SNAP-Tag® and CLIP-Tag TM represent versatile tools for the specific, covalent attachment of in principle any molecule of choice to a protein of interest. Discover our substrates!
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Argpyrimidine is the result of a Maillard Reaction-like nonenzymatic posttranslational modification. You want to investigate the effect of this change on function and stability? Get the building block!
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March 9th - 12th, 2023
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We are pleased to serve as your platform – either to highlight your science performed with our building blocks or to market innovative building blocks you are developing! Read on for more information!
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PEGs are being used as spacers, as hydrophilic decoration, and building blocks. Read on for more detailed information about the reactivity of different PEG derivatives and how to use them.
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Maleimides provide versatile options for connecting payloads to proteins and other biomolecules. Discover how our bifunctional thiol reactive crosslinkers can support your project. Read on!
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Coupling Reagents are required for the formation of an amide or ester bond. As simple as those reactions seem to be, the choice of the appropriate reagent is crucial for optimizing purity and yield.
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Non-canonical Tryptophan analogs can help to improve your API’s performance in terms of potency, specificity, and stability. We offer various substituted Trp derivatives also available in small quantities for screening.
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Our monofunctionalized dextrans are enriching the toolbox of polymer therapeutics – Dextrans benefit of excellent solubility, biocompatibility, biodegradability, and non-immunogenicity.
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From evolution to solution - natural products are an infinite source of (bio)active compounds. In this series we present how natural products can be conjugated to empower their inherent potential.
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From beginning of May until end of July 2023 we offer special polysarcosine bundles each containing three functionalized PSars of different molecular weight (5 kDa, 10 kDa, 15 kDa), 100 mg each.
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Peptide therapeutics – fewer injections/lower doses by prolonging their half-life via addition of a lipid modification that promotes binding to serum proteins such as albumin. Read on for recent innovations!
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Building blocks with a strained triple bond do not require copper catalysis when used in click chemistry. Discover CliCr®: improved solubility in aqueous conditions and high reactivity! Click here!
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Our building block Fmoc-L-Cys(Cam)-OH enables peptides resembling reduced and carbamido-methylated protein fragments by standard SPPS without error-prone modification reactions.
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You missed our workshop featuring Prof. Rob Liskamp (Cristal Therapeutics, University of Maastricht, University of Glasgow)? Any further questions? Please get in contact via info@iris-biotech.de.
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Plasma technology allows to equip inert polymers such as poly(ethylene) or polystyrene with functional groups like amine or carboxylate enabling further conjugations and applications. Read on!
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Discover our diazirine-substituted building blocks suitable for the analysis of protein-protein and RNA-protein interactions via proximity labeling upon photoactivation. Read on for more information!
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Add a new dimension of orthogonality to your peptide synthesis by using Safety-Catch arylalkyl sulfoxide protecting groups! This newsletter tells you about benefits and usage – Read on!
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Curious about our latest portfolio additions from January to June 2023? Discover our New Products Flyer and check out the summary of recent product highlights! Get in contact for more details!
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Allotropes of carbon show distinct characteristics in structure and e.g. electric and biophysiological properties. Discover how these materials can be further exploited by linker attachment!
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The potential of natural products of daily life , such as 6-shogaol from ginger ( Zingiber officinale) , can flourish if the active ingredient is conjugated to an appropriate carrier via Linkerology®.
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TCEP is an effective reductant for disulfide bonds and a versatile reagent for various applications in protein science with distinct advantages compared to DTT and BME.
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Bioengineering in combination with Linkerology® . Check out the unique options for membrane proteins, recombinant immunotoxins (RITs) and novel antibody-drug conjugates.
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You want to attach your small molecule to a certain carrier? Let’s analyze the functional groups present and discuss Linkerology® possibilities for permanent or trigger-inducible, tracelessly-cleavable linkage.
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Ongoing research efforts lead to the discovery of innovative building blocks and new APIs. However, for industrial applications, upscaling is required. Herein, we share the process development for Fmoc-Cys(Msbh)-OH.
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You missed our workshop featuring Dr. Stefan Kubick (B4Pharmatech, Berlin)? Any further questions? Please get in contact via info@iris-biotech.de
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Sick of Lysine side chain protecting groups jumping around, yielding scrambled peptides? Check our various options to fine-tune protecting group stability vs. cleavability to optimize your peptide yield.
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A heart of gold! Metals and ores - see here how their surfaces can be equipped with bifunctional organic linker molecules and thus be turned into modifiable biocompatible materials.
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Discover our small-sized, neutral Fmoc-protected nitrobenzoselenadiazole- and nitrobenzothiadiazole-modified amino acids suitable for SPPS of fluorescent peptides.
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The discovery of the Merrifield peptide synthesis paved the way for automated solid-phase peptide synthesis (SPPS) enabling fast and convenient simultaneous peptide synthesis.
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Discover possibilities to fight chronic pain diseases by employing linker technologies. Check out the options for multiple drug conjugation in combination with different release mechanisms.
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Add glycans to your proteins with our ready-to-use Fmoc asparagine building blocks suitable for solid phase peptide synthesis and produce peptides with exactly defined glycosylation patterns!
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You missed our workshop featuring Dr. Quibria Guthrie (CEM Corporation)? Any further questions? Please get in contact via info@iris-biotech.de.
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Curious about the highlights of our 2023 portfolio additions? Discover innovative building blocks and latest technologies! Read on to check out the summary or get in contact if you need more details!
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REACH regulation for the handling of N , N -dimethylformamide (DMF), the most commonly used solvent for solid-phase peptide synthesis (SPPS). Read more about consequences and alternatives!
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Increase your peptide’s stability, introduce an NMR label for analysis, or enhance lipophilicity. Read our blog to discover our latest toolbox additions in the field of non-canonical amino acids.
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Are you keen on developing novel billion-dollar-selling peptide API blockbusters? Most recent ones use lipophilic Albumin binding moieties. Of course, Iris Biotech has the necessary building blocks!
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The tetrazole isostere of malonyllysine is thermally stable and does not suffer from decarboxylation. Discover our building blocks suitable for incorporation via solid-phase peptide synthesis.
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You are looking for a building block suitable to control the folding characteristics of your peptide or want to add a pH-sensitive conformational switch? Discover aminoprolines and their properties!
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Explore phenylisopropylesters (OPP/OPis) as carboxy protecting groups. Facilitate your peptide synthesis with building blocks for precise side chain modifications or seamless macrolactamizations.
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Boron is not boring at all! Today, we'll delve deeper into the exciting world of boronate-containing amino acid building blocks and unlock the potential of the next generation of peptides. Read on!
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You missed our workshop featuring Dr. Fabio de Moliner & Prof. Dr. Marc Vendrell? Watch the Recording! Any further questions? Please get in contact via info@iris-biotech.de.
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Engineer shape-shifting peptides , controllable by a laser as magic wand! In this newsletter, we’ll explore the possibilities of photo switchable building blocks based on azobenzene.
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You are looking for monodisperse Sarcosines ? You want to use Sarcosine for SPPS? You need to improve your drug's hydrophilicity and search for PEG alternatives? Read on!
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Beyond cysteines: Unlock targeted side-chain modifications of your peptides and proteins via the introduction of 1,2-aminothiols and subsequent click-like functionalization.
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Have an additional ace up your sleeve for selective and efficient peptide modification, cyclization, and/or bioconjugation. Explore 2-cyanopyridines for click-like reactions. Get more information!
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Discover photocages – photosensitive protecting groups that are removed by irradiation with light of a defined wavelength, thus restoring the original, “active” state.
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Level up! Carboxymethyl-modified amino acid building blocks suitable for incorporation by solid-phase peptide synthesis. Learn more about available derivatives and their properties.
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