Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Currency
USD
Quick contact
Please send me more information about
Aloc-L-Arg(Pbf)-OH
Chemical name: N-alpha-Allyloxycarbonyl-N'-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine // Synonyms: Aloc-Arg(Pbf)-OH, Alloc-Arg(Pbf)-OH, (S)-2-(allyloxycarbonylamino)-5-(3-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-ylsulfonyl)guanidino)pentanoic acid, Alloc-L-Arg(Pbf)-OH
- Product code:AAA2030
- CAS No.:783371-61-9
- Formula:C23H34N4O7S
- Molecular weight:510.6 g/mol
- Purity :min. 98%
- Enantiomeric Purity:min. 99,7%
Starting at $112.50
description
Reported for the synthesis of an Arg analogue of Teixobactin, where L-Arg (linear) replaced the L-allo-enduracididine (cyclic) residue as both of these building blocks are guanidine-based amino acids. The Aloc protecting group is fully compatible with Fmoc/tBu and Boc/Bzl strategies. N-Allyloxycarbonyl (Aloc) are widely used protecting groups, i.e. for amines and amino acids, as they are quantitatively and very rapidly converted to free amino compounds by palladium. The 2,2,4,6,7-pentamethyIdlhydrobenzofuran-5-sulfonyl group (Pbf) can be easily cleaved by trifluoroacetic acid (TFA).
references
Synthesis of a PNA-encoded cysteine protease inhibitor library; F. Debaene, L. Mejias, J. L. Harris, N. Winssinger; Tetrahedron 2004; 60(39): 8677-8690. https://doi.org/10.1016/j.tet.2004.05.107.
Synthesis and Biological Evaluation of a Teixobactin Analogue; Y. E. Jad, G. A. Acosta, T. Naicker, M. Ramtahal, A. El-Faham, T. Govender, H. G. Kruger, B. G. de la Torre, F. Albericio. Org. Lett. 2015; 17(24): 6182-6185. https://doi.org/10.1021/acs.orglett.5b03176.
Preparation of compounds having amino acid residue or peptide residue and process for producing the same; H. Ikeda, M. Tonosaki; PCT Int. Appl. Patent 2006; WO2006115230 A1.
Bulk or large quantity order?
Do you need larger quantities for your development or production?
Do you need further information about this product?
get in contact
Related Products
We found other products you might like!
