PROTACs for Click Chemistry  

PROTACs for Click Chemistry  

Targeted protein degradation via proteolysis-targeting chimeras (PROTACs) is an emerging attempt to cure diseases caused by the irregular expression of certain disease-causing proteins. To construct a suitable PROTAC, we provide a variety of E3 ubiquitin ligase ligands in combination with linkers of various length and an elective click-reactive end.