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Reagents
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Abraligabra - Reagents and Building Blocks for Chemical Ligation
We can’t get enough of new products and innovations! Read this blog to get detailed information on the cyanylating reagent NTCB as well as selenocysteine amino acids, both useful tools for peptide ligation.
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DTT and Spermidine for RNA Buffers and Vaccine Production
See how our “mRNA grade” DTT and Spermidine can support also your nucleic acid production. Read on for more information.
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Process Development of SPPS
From mg synthesis of a peptide up to bulk quantities often makes a huge difference in the route of production. Read on for more information about Iris Biotech’s process development services.
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PotM: 1,4-Benzenedimethanethiol (BDMT)
1,4-Benzenedimethanethiol is used as thiol scavenger during solid-phase peptide synthesis. In comparison to other thiol scavengers, this reagent is odorless and provides high quality crude peptides.
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Product of the Month: “Cleland’s Reagent” Dithiothreitol (DTT)
DTT is a powerful yet mild reducing agent. Based on your demand we can offer different quality grades to suit your needs.
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Fmoc-Amox, A Novel Reagent for Fmoc-Protection
The most common reagent for the Fmoc-protection of amino acids is currently Fmoc-OSu, followed by Fmoc-Cl. However, the use of these reagents is usually accompanied by several side reactions, such as the formation of beta-alanine and dipeptides.
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Fmoc Deprotection Reagents
The Fmoc group is the most frequently used protecting group in peptide chemistry. The most common deprotection conditions involve a solution of 20% piperidine in DMF.
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Coupling Reagents for Peptide Chemistry
In this news section, we highlight three useful coupling reagents for peptide chemistry: PyCLOCK, PyAOP and HDMA.
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THPTA: Ligand-accelerated Click Chemistry in Aqueous Solution
Polytriazole ligands such as THPTA accelerate the copper-catalyzed azide-alkyne cycloaddition (CuAAC), or “Click”, reaction. Moreover, with the use of further additives, polytriazoles facilitate CuAAC even in live cells by significantly lowering the bioavailability of the copper catalyst.
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Targeted and Reversible Biotinylation with Biotin-SS-Tyramide
Our new Biotin-SS-Tyramide linker is a valuable tool for peroxidase-promoted targeted protein biotinylation. By using peroxidase-tagged antibodies, proteins and protein clusters can be selectively biotinylated, and then isolated using streptavidin. The biotin tag can be subsequently removed using reducing agents (e.g. glutathione).
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