Amino Acids

  1. PotM: Seleno Amino Acids

    Selenocysteine (Sec) plays a crucial role for various biological processes, and selenoproteins can be found in all lineages of life. Read on to discover the 21st amino acid, its derivatives and applications.

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  2. Protease Stable Ile/Leu Surrogates

    Herein we are presenting 2-(Fmoc-amino)-3,3-diMe-pent-4-enoic acid (FAA5040), a protease stable Ile/Leu surrogate suitable for further modification via its side chain double bond.

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  3. Measures to Prevent Aspartimide Formation

    Aspartimide formation remains one major hurdle during peptide synthesis. Read on to find out more about different strategies and available products at Iris Biotech in order to avoid this side product.

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  4. Avoiding Racemization: Fmoc-Aaa-MPPAs as Alternatives for Wang Linker during SPPS

    Compounds of the shown formula can simply be bound to solid supports via amide bond formation without racemization of the C-terminal amino acid and enable the synthesis of very pure peptides.

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  5. Trifluoromethylated Amino Acids

    The incorporation of alpha-trifluoromethyl substituted amino acids into peptides increases proteolytic stability, enhances lipophilicity, and induces secondary structures. Read on to find out more!

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  6. Fmoc-L-Cys(Palm)-OH – A S-palmitoylated Cysteine building block

    Interested in studying the effect of palmitoylation on your peptide’s localization, function, and stability? Read on to find out more about the use of lipidated “fatty” amino acids!

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  7. Facilitating the synthesis of hydrophobic peptides and proteins

    Cys(Aapam): an Alloc protected Phacm linker as removable side chain modification for the incorporation of e.g. solubilizing tags facilitating the preparation of hydrophobic peptides and proteins.

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  8. PotM: Guanidino-Proline as rigid Arginine mimic

    Interested in structure activity studies on your Arginine containing peptide or further optimization for improved receptor binding? Explore our guanidino Proline derivatives as rigid Arginine mimics.

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  9. PotM: Asp(CSY) – Tackling Aspartimide Formation

    Fmoc-Asp(CSY)-OH – an innovative building block to suppress aspartimide formation during peptide synthesis by utilizing cyanosulfurylide as carboxylic acid protecting group. Read on to find our more!

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  10. Adamantyls are a Chemist’s Best Friend

    The highly lipophilic, bulky adamantyl motif is a promising and validated building block to increase the drug-qualities of lead compounds without increasing their toxicity.

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