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Amino Acids
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PotM: SIT – A New Cysteine Protecting Group
The new disulfide-based protecting group sec-isoamyl mercaptan (SIT) is fully compatible with Fmoc- and Boc-SPPS and can easily be removed reductively upon addition of dithiothreitol.
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Cyclopropyl Modification
Cyclopropanes represent important design elements in medicinal chemistry and are widely present in drug compounds. Read on to find out more about their full potential.
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Amino-Methylcoumarins as Fluorescent Labels
Enzymatically-activatable probes based on 7-amino-4-methylcoumarin (AMC) represent versatile tools for the detection and localization of proteolytic enzyme activities. Read on to find out more.
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Modifications of Methionine
Methionine is particularly prone to oxidation by atmospheric oxygen in vitro but also by reactive oxygen species in vivo, resulting in the corresponding sulfoxide and sulfone. Read on to find out more.
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Product of the Month: Fluorinated Amino Acids
One approach for the design of bioactive peptides with improved pharmacological properties is the derivatization of amino acid building blocks with fluorine. Find out more about the advantages of fluorinated peptides.
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Nitrodibenzofuran (NDBF) based Photocleavable Protecting Groups
Nitrodibenzofuran (NDBF) is a photocleavable side chain protecting group that can be removed by photolysis upon irradiation with UV-light or – especially for in vivo applications – by two-photon excitation using near infrared light.
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Product Focus: Next Generation Phosphoamino Acid Analogs
Iris Biotech presents the next-generation of hydrolysis-stable phosphono-analogs of pSer, pThr and pTyr. Fluorination renders the phosphonic acid more acidic and thus an even better mimic of the parent phosphoamino acid.
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Product Focus: Arginine Derivatives
Looking to optimize or functionalize your peptide? Explore our ever-growing selection of Arg derivatives and find the one suitable for your application.
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Product of the Month: Novel Fmoc-Amino Acids for Convenient Access to HDAC Inhibitors
Find out more about those building blocks with side chains able to coordinate metal ions, and why peptide-based HDACis are intriguing synthetic targets.
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Alkyne Amino Acids for Click Chemistry and other Conjugations:
Alkyne amino acids allow for Click conjugations and other types of chemistry. Read more about alkyne-functionalized amino acids and our related products.
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