Building Blocks

  1. Thiol-reactive Linkers for ADCs

    The thiosuccinimide linkage is a prominent connective motif resulting from the reaction of a thiol and an alkyl maleimide. Read on to learn more about its applications and potential improvements.

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  2. Deamino- and Decarboxy-Histidine Derivatives

    Interested in histidine derivatives? Iris Biotech provides a selection of deamino- and decarboxy-products. Find out more about benefits and potential applications of our new building blocks.

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  3. Building Blocks for the SPPS of FRET-based fluorogenic protease substrates

    The classic FRET pair EDANS and DABCYL is now available linked to Fmoc amino acid building blocks that can be readily used in SPPS. Conveniently synthesize your own custom protease substrates!

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  4. NGlyO – for beta sheet formation

    Surprising behavior of NXO-peptides.
    It is a significant property of peptides that oxalo-retro azapeptides have the same donor and acceptor distances and properties for hydrogen bridge formation as a tripeptide fragment and therefore induce beta-sheet formation at this position.

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  5. Peptoids - Peptide Backbone Derivatisation

    Alkylating the Nitrogen of an amide bond results in peptoid structures, leading to conformational restrains, like N-methylation and allows backbone derivatisation. Applications already have been published with Cilengitide, Piscidin 1, and MC4 receptor agonist.

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  6. Improved Synthesis with Dmb-Glycine Dipeptide Building Blocks

    Positions next to Glycine are often reasons for side reactions, as aspartamide or diketopiperazine formation can occur. Dmb and Tmb can be used for temporary protection of the amide nitrogen of a peptide bond, in order to solubilize the peptide and increase yield and purity.

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  7. Diamines & Polyamines

    Compounds like putrescine, spermidine, and spermine play important roles in a many biological functions. Many of them are excellent targets for oncology studies and other fields of medicinal chemistry.
    Find in our new brochure Diamines & Polyamines our possibilities for custom synthesis and a set over 100 available derivatives.

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  8. NProO Building Blocks for fast and efficient synthesis of γ-turns in peptides

    Any amino acid can be functionalized on the N-terminus with oxalic acid and on the C-terminus with hydrazine, in order to form a so-called NXO building block. Through this double modification N and C terminus will be inverted, which provides interesting structural options for peptidomimetics.

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  9. Nosyl-Amines

    Activation AND Protection SIMULTANEOUSLY
    A smart technology for avoiding over-alkylation of primary amines

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