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Polyamines & Spermines
Polyamines are organic compounds with at least two primary amino groups. Around neutral pH, they exist as their charged ammonium derivatives. Polyamines are known to stabilize nucleic acids against chemical and enzymatic degradation, facilitate the formation of secondary and tertiary structures, and enhance cellular uptake. Biogenic polyamines, such as putrescine and spermidine are able to bind to DNA and RNA and cause DNA condensation and aggregation inducing DNA conformational changes.
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