1. N-Alkyl Substituted Carboxy Linkers for Peptide Synthesis

    Herein, we present Fmoc-protected N-alkyl-substituted carboxy linkers, which can be elongated by Fmoc-SPPS and can easily be linked to amino-functionalized solid supports. Read on to find out more about their advantages.

    read more
  2. Enzymatically Cleavable Linkers Based on Val-Cit and Val-Ala

    The peptide-based ADC linkers Val-Cit and Val-Ala are efficiently cleaved by lysosomal proteases and benefit from increased serum stability and effective payload-release in targeted cells.

    read more
  3. Thiol- and Amine Reactive Crosslinkers

    Iris Biotech offers hetero-bifunctional crosslinkers bearing an N-hydroxysuccinimide (NHS) ester and a maleimide group suitable for the reaction with amine- and thiol-containing molecules.

    read more
  4. PotM: Pyridyldithiols as Precursors for Disulfide-Based (Self-Immolative) Linkers

    Read on to find out more about Iris Biotech’s Linkerology® portfolio including substituted pyridyldithiols as building blocks for the reversible chemical conjugation to sulfhydryls.

    read more
  5. Fmoc-MeDbz-OH – Available on Large Scale

    Are you using the Fmoc-MeDbz-OH Dawson Linker in large scale on a regular basis? A robust and economic processallows us to promptly provide you with kg quantities at competitive prices and in high quality.

    read more
  6. DACNs for Strain-Promoted Azide-Alkyne Cycloadditions (SPAAC)

    Herein we present substituted diazacyclononynes (DACNs) as versatile tools for metal-free strain-promoted Click Chemistry that are characterized by high reactivity and stability, both thermally and chemically.

    read more
  7. Ramage Linker

    An efficient, versatile linker developed for the synthesis of C-terminal primary/secondary amides and hydrazides as well as peptide alcohols, which is compatible with SPPS and suppresses side reactions.

    read more
  8. Trimethyl Locks

    The sterical interference of three closely positioned methyl groups favors amide cleavage and payload release upon lactonization. This cascade can be induced by various triggers. Read on to find out more.

    read more
  9. PotM: Disulfide-Based Self-Immolative Linkers

    The linkage of a drug to its carrier via a disulfide-based self-immolative linker allows for the specific intracellular release of the active molecule upon glutathione reduction and linker cleavage.

    read more
  10. Linkerology

    Check out our latest video summarizing our capabilities and knowledge on linker technologies

    read more

Items 1-10 of 24

Show per page