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Linkerology
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PotM: Multiconjugates via Simultaneous Double-Click Reaction
Discover our new building block 4-(azido-propyl-tetrazine)phenylalanine (pTAF) and make use of the orthogonality of the 2nd and 3rd generation Click reaction to build multiconjugates via double-Click.
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Conjugating Small Molecule Drugs
You want to attach your small molecule to a certain carrier? Let’s analyze the functional groups present and discuss Linkerology® possibilities for permanent or trigger-inducible, tracelessly-cleavable linkage.
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Cell-Free Bioengineering & Linkerology®
Bioengineering in combination with Linkerology®. Check out the unique options for membrane proteins, recombinant immunotoxins (RITs) and novel antibody-drug conjugates.
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Conjugating Natural Products (3)
The potential of natural products of daily life, such as 6-shogaol from ginger (Zingiber officinale), can flourish if the active ingredient is conjugated to an appropriate carrier via Linkerology®.
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Functionalization of Carbon Materials by Linker Attachment
Allotropes of carbon show distinct characteristics in structure and e.g. electric and biophysiological properties. Discover how these materials can be further exploited by linker attachment!
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Functionalization of (Inert) Polymeric Surfaces
Plasma technology allows to equip inert polymers such as poly(ethylene) or polystyrene with functional groups like amine or carboxylate enabling further conjugations and applications. Read on!
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Conjugating Natural Products (2)
Infinite like the deep sea – marine natural products are an infinite source of (bio)active compounds. In this series we present how natural products can be conjugated to empower their inherent potential.
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Conjugating Natural Products (1)
From evolution to solution - natural products are an infinite source of (bio)active compounds. In this series we present how natural products can be conjugated to empower their inherent potential.
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Maleimide Crosslinkers
Maleimides provide versatile options for connecting payloads to proteins and other biomolecules. Discover how our bifunctional thiol reactive crosslinkers can support your project. Read on!
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PotM: Perfluorobiphenyl Building Blocks for Site-Selective Cysteine Conjugation
Herein, we present functionalized perfluorobiphenyl building blocks which can be used for site-selective π-clamp mediated cysteine conjugation. Read on for more details about this general method!
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