Hydrazone Resins

Hydrazone Resins

Peptide hydrazides can be easily synthesized using the novel hydrazone resin. The hydrazone linker is completely stable in the course of standard Fmoc SPPS and tolerates treatment with 5% TFA/DCM. Subsequent application of TFA:water:TIS 95:2.5:2.5 as cleavage cocktail permits to obtain the peptides in good yields and purities.