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Abstract: A symposium report. Protected peptides were synthesized using 9-fluorenylmethoxycarbonyl (Fmoc) amino acids and the acid labile 2-chlorotrityl and the multidetachable 2-chlorotrityl-Rink-linker resins.read more
Wang resins are widely used for peptide synthesis. However, certain side reactions, like diketopiperazin formation limit their use. 4-Methylbenzhydryl resin needs more space and leaves less room for this type of side reactions. Standard “Wang-typical” Fmoc/tBu coupling protocols can be applied.read more
Peptide hydrazides can be easily synthesized using a new hydrazone resin, obtained via acylation of aminomethyl polystyrene by Fmoc-hydrazone of pyruvic acid.read more
Fmoc-Sieber amide resin is an acid-labile carrier for solid phase synthesis of peptide amides. Cleavage with only 1% TFA makes it an ideal carrier for the synthesis of protected peptide fragments in fragment condensation strategies for the synthesis of long peptides.read more
Used for Efficient and Economic Bulk Synthesis of Peptide APIs:
A new technology is available with a set of new preloaded resins, which enable the synthesis of peptide amides WITHOUT ANY LINKER.
Amino acid amides, which bear a functional side chain, are immobilized on acid sensitive resins. This makes process development, small scale synthesis, bulk production and in-process control very easy.
Find more technical details in our application for demonstration purposes with BIVALIRUDIN.read more
Fmoc-Sieber amide resin is an acid-labile carrier for solid phase synthesis of peptide amides. Cleavage can be achieved with only 1% TFA in DCM making them an ideal carrier for the synthesis of protected peptide fragments in fragment condensation strategies for the synthesis of long peptides. It has also been used in organic synthesis of acid-sensitive compounds, for targeted synthesis of primary amines and N-alkylated secondary carboxyamides.read more
In our section RESINS/Mercapto Acids/Thiol Resins:
there are Sulphur carrying building blocks linked through Sulphur to different resin supports. In the case of Amino Thiols the side chains are same as in natural proteinogenic amino acids. The amino group is unprotected and free for any coupling steps via standard SPPS protocols, in order to build up a suitable peptide sequence.
After cleavage from the resin (with trifluoroacetate using triethylsilane or ethanedithiol as scavenger) a peptide is being designed, which carries a thiol group on the C-terminus. As sulphur has high affinity to heavy metals, like Zn, Fe or Ni, which are essential metal centers in metallo proteins, the affinity of peptide substrates or pharmacological active sequences can further be increased through a strong sulphur-metal interaction.