Publication

  1. Solid-Phase Peptide Synthesis Using a Four-Dimensional (Safety-Catch) Protecting Group Scheme

    As the molecular diversity of cyclic and branched peptides becomes more and more challenging, a high level of orthogonal dimensionality is required. Herein, we present a new category of orthogonal protecting groups.

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  2. Solid-Phase Synthesis of an “Inaccessible” hGH-Derived Peptide Using a Pseudoproline Monomer and SIT-Protection for Cysteine

    Herein, we report the first-time SPPS of a special peptide sequence via employment of of a serine pseudoproline building block as well as sec-isamyl mercaptan (SIT) as cysteine protecting group.

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  3. 2-Chlorotrityl Chloride and 4-Methylbenzhydryl Bromide Resin Loading Using the Mixture of Organic Solvents: A “Greener” Alternative to Dichloromethane and N,N-Dimethylformamide

    Common protocols for the loading of 2-CTC and MBH-Br resins presume the application of DCM, THF, or DMF; these solvents are considered as undesirable in accordance with modern regulatory rules.

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  4. Easy access to purified complex peptides on larger scales with the peptide easy clean technology – a liraglutide case study

    With a remarkable amount of peptide therapeutics already on the market and many more to come, there is an ongoing need to improve manufacturing scale and efficiency for a sustainable, global supply.

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  5. Innovative ways to fight SARS-CoV-2

    With the approval of several COVID-19 vaccines and drugs in recent months, hope is growing that the current pandemic will end soon.

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  6. Short arginine analogs: peptide synthesis prediction of biological effects

    Arginine, a semi-essential amino acid, is involved in various important metabolic processes.

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  7. Influence of arginine mimetics on the biological effects of NT(8-13) analogues

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  8. Synthesis of RGD Peptides Inducing Multicellular Spheroids Formation

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  9. In vitro assessment of the cytotoxic effects of novel RGD analogues and conjugates

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  10. Convenient method of peptide hydrazide synthesis using a new hydrazone resin

    Peptide hydrazides can be easily synthesized using a new hydrazone resin, obtained via acylation of aminomethyl polystyrene by Fmoc-hydrazone of pyruvic acid.

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