Blog

  1. PotM: SIT – A New Cysteine Protecting Group

    The new disulfide-based protecting group sec-isoamyl mercaptan (SIT) is fully compatible with Fmoc- and Boc-SPPS and can easily be removed reductively upon addition of dithiothreitol.

    read more
  2. Cyclopropyl Modification

    Cyclopropanes represent important design elements in medicinal chemistry and are widely present in drug compounds. Read on to find out more about their full potential.

    read more
  3. 5th ECP

    February 24-26, 2021

    read more
  4. Trimethyl Locks

    The sterical interference of three closely positioned methyl groups favors amide cleavage and payload release upon lactonization. This cascade can be induced by various triggers. Read on to find out more.

    read more
  5. PotM: Disulfide-Based Self-Immolative Linkers

    The linkage of a drug to its carrier via a disulfide-based self-immolative linker allows for the specific intracellular release of the active molecule upon glutathione reduction and linker cleavage.

    read more
  6. Linkerology

    Check out our latest video summarizing our capabilities and knowledge on linker technologies

    read more
  7. VIRTUAL BPS

    January 19, 2021

    read more
  8. New Dawson Linker Derivatives

    Interested in the formation of peptide thioesters for Native Chemical Ligation? Read on to find out more about the use of Dawson Linker derivatives as thioester surrogates compatible with Fmoc SPPS.

    read more

Items 1-10 of 409

Page
Show per page