Blog

  1. Avoiding Racemization: Fmoc-Aaa-MPPAs as Alternatives for Wang Linker during SPPS

    Compounds of the shown formula can simply be bound to solid supports via amide bond formation without racemization of the C-terminal amino acid and enable the synthesis of very pure peptides.

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  2. Enzymatically Cleavable Linkers Based on Val-Cit and Val-Ala

    The peptide-based ADC linkers Val-Cit and Val-Ala are efficiently cleaved by lysosomal proteases and benefit from increased serum stability and effective payload-release in targeted cells.

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  3. Trifluoromethylated Amino Acids

    The incorporation of alpha-trifluoromethyl substituted amino acids into peptides increases proteolytic stability, enhances lipophilicity, and induces secondary structures. Read on to find out more!

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  4. PotM: Methanoprolines and Dimethylprolines - Constraining the Conformation of Peptides

    Interested in structure-activity studies of your Proline-containing peptide drug? Find out more about the use of Methanoprolines and Dimethylprolines as conformational amide locks.

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  5. Innovative ways to fight SARS-CoV-2

    With the approval of several COVID-19 vaccines and drugs in recent months, hope is growing that the current pandemic will end soon.

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  6. RICT 2021

    July 7th - 9th, 2021

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  7. Clicky Acids – Fatty Acids for Click Conjugation

    Iris Biotech offers various (protected) azide- and alkyne-modified fatty acid derivatives suitable for Click Chemistry. Interested? Read on to find out more!

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  8. About the Advantages of Pseudoproline Dipeptides

    Serine- and Threonine-derived oxazolidines as well as Cysteine-derived thiazolidines, so-called Pseudoprolines, serve as structure-disrupting, solubilizing building blocks in peptide synthesis.

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  9. Thiol- and Amine Reactive Crosslinkers

    Iris Biotech offers hetero-bifunctional crosslinkers bearing an N-hydroxysuccinimide (NHS) ester and a maleimide group suitable for the reaction with amine- and thiol-containing molecules.

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  10. PotM: Pyridyldithiols as Precursors for Disulfide-Based (Self-Immolative) Linkers

    Read on to find out more about Iris Biotech’s Linkerology® portfolio including substituted pyridyldithiols as building blocks for the reversible chemical conjugation to sulfhydryls.

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