Hydroxymethyl/AC/PAM/HMBA Resins

Hydroxymethyl/AC/PAM/HMBA Resins

The hydroxymethyl resin analog was invented to avoid unwanted side reactions, which can occur for unreacted chloromethyl groups in the case of incomplete Merrifield resin loading. For this resin, free hydroxyl groups can be capped with acetic anhydride. The 4-hydroxymethyl-3-methoxyphenoxyacetic (AC; sometimes also MHMPA) linker is even more acid labile than the Wang resin. The peptide acid can be cleaved from the resin with 1% TFA. The 4-hydroxymethyl-phenylacetamidomethyl functionalized PAM resin is widely used in Boc-chemistry, as it is more stable towards acids. Resins with hydroxymethylbenzoic acid (HMBA) are stable to acidic cleaving conditions. Cleavage from the resin is achieved by a range of nucleophiles.

  1. Structure image for Boc-Gly-PAM Resin
    Boc-Gly-PAM Resin

    Product code: PAM5635

    Particle size : 100-200 mesh

  2. Structure image for Boc-L-Ala-PAM Resin
    Boc-L-Ala-PAM Resin

    Product code: PAM5600

    Particle size : 100-200 mesh

  3. Structure image for Boc-L-Arg(Mts)-PAM Resin
    Boc-L-Arg(Mts)-PAM Resin

    Product code: PAM5606

    Particle size : 100-200 mesh

  4. Structure image for Boc-L-Arg(Tos)-PAM Resin
    Boc-L-Arg(Tos)-PAM Resin

    Product code: PAM5605

    Particle size : 100-200 mesh

  5. Structure image for Boc-L-Asn-PAM Resin
    Boc-L-Asn-PAM Resin

    Product code: PAM5610

    Particle size : 100-200 mesh

  6. Structure image for Boc-L-Asp(Bzl)-PAM Resin
    Boc-L-Asp(Bzl)-PAM Resin

    Product code: PAM5615

    Particle size : 100-200 mesh

  7. Structure image for Boc-L-Asp(cHx)-PAM Resin
    Boc-L-Asp(cHx)-PAM Resin

    Product code: PAM5616

    Particle size : 100-200 mesh

  8. Structure image for Boc-beta-Ala-PAM Resin
    Boc-beta-Ala-PAM Resin

    Product code: PAM5601

    Particle size : 100-200 mesh

  9. Structure image for Boc-L-Cys(4-MeBzl)-PAM Resin
    Boc-L-Cys(4-MeBzl)-PAM Resin

    Product code: PAM5620

    Particle size : 100-200 mesh

  10. Structure image for Boc-L-Cys(4-MeOBzl)-PAM Resin
    Boc-L-Cys(4-MeOBzl)-PAM Resin

    Product code: PAM5621

    Particle size : 100-200 mesh

  11. Structure image for Boc-L-Cys(Acm)-PAM Resin
    Boc-L-Cys(Acm)-PAM Resin

    Product code: PAM5622

    Particle size : 100-200 mesh

  12. Structure image for Boc-L-Gln-PAM Resin
    Boc-L-Gln-PAM Resin

    Product code: PAM5625

    Particle size : 100-200 mesh

  13. Structure image for Boc-L-Glu(Bzl)-PAM Resin
    Boc-L-Glu(Bzl)-PAM Resin

    Product code: PAM5630

    Particle size : 100-200 mesh

  14. Structure image for Boc-L-Glu(cHx)-PAM Resin
    Boc-L-Glu(cHx)-PAM Resin

    Product code: PAM5631

    Particle size : 100-200 mesh

  15. Structure image for Boc-L-His(Dnp)-PAM Resin
    Boc-L-His(Dnp)-PAM Resin

    Product code: PAM5638

    Particle size : 100-200 mesh

  16. Structure image for Boc-L-His(Tos)-PAM Resin
    Boc-L-His(Tos)-PAM Resin

    Product code: PAM5637

    Particle size : 100-200 mesh

  17. Structure image for Boc-L-Ile-PAM Resin
    Boc-L-Ile-PAM Resin

    Product code: PAM5640

    Particle size : 100-200 mesh

  18. Structure image for Boc-L-Leu-PAM Resin
    Boc-L-Leu-PAM Resin

    Product code: PAM5645

    Particle size : 100-200 mesh

  19. Structure image for Boc-L-Lys(2-Cl-Z)-PAM Resin
    Boc-L-Lys(2-Cl-Z)-PAM Resin

    Product code: PAM5650

    Particle size : 100-200 mesh

  20. Structure image for Boc-L-Lys(Fmoc)-PAM Resin
    Boc-L-Lys(Fmoc)-PAM Resin

    Product code: PAM5651

    Particle size : 100-200 mesh

  21. Structure image for Boc-L-Met-PAM Resin
    Boc-L-Met-PAM Resin

    Product code: PAM5655

    Particle size : 100-200 mesh

  22. Structure image for Boc-L-Met(O)-PAM Resin
    Boc-L-Met(O)-PAM Resin

    Product code: PAM5656

    Particle size : 100-200 mesh

  23. Structure image for Boc-L-Nle-PAM Resin
    Boc-L-Nle-PAM Resin

    Product code: PAM5659

    Particle size : 100-200 mesh

  24. Structure image for Boc-L-Orn(Z)-PAM Resin
    Boc-L-Orn(Z)-PAM Resin

    Product code: PAM5658

    Particle size : 100-200 mesh

  25. Structure image for Boc-L-Phe-PAM Resin
    Boc-L-Phe-PAM Resin

    Product code: PAM5660

    Particle size : 100-200 mesh

  26. Structure image for Boc-L-Pro-PAM Resin
    Boc-L-Pro-PAM Resin

    Product code: PAM5665

    Particle size : 100-200 mesh

  27. Structure image for Boc-L-Ser(Bzl)-PAM Resin
    Boc-L-Ser(Bzl)-PAM Resin

    Product code: PAM5670

    Particle size : 100-200 mesh

  28. Structure image for Boc-L-Thr(Bzl)-PAM Resin
    Boc-L-Thr(Bzl)-PAM Resin

    Product code: PAM5675

    Particle size : 100-200 mesh

  29. Structure image for Boc-L-Trp(CHO)-PAM Resin
    Boc-L-Trp(CHO)-PAM Resin

    Product code: PAM5681

    Particle size : 100-200 mesh

  30. Structure image for Boc-L-Trp-PAM Resin
    Boc-L-Trp-PAM Resin

    Product code: PAM5680

    Particle size : 100-200 mesh

  31. Structure image for Boc-L-Tyr(2,6-Cl2-Bzl)-PAM Resin
    Boc-L-Tyr(2,6-Cl2-Bzl)-PAM Resin

    Product code: PAM5662

    Particle size : 100-200 mesh

  32. Structure image for Boc-L-Tyr(2-Br-Z)-PAM Resin
    Boc-L-Tyr(2-Br-Z)-PAM Resin

    Product code: PAM5686

    Particle size : 100-200 mesh

  33. Structure image for Boc-L-Val-PAM Resin
    Boc-L-Val-PAM Resin

    Product code: PAM5690

    Particle size : 100-200 mesh

  34. Structure image for Boc-D-Ala-PAM Resin
    Boc-D-Ala-PAM Resin

    Product code: PAM5700

    Particle size : 100-200 mesh

  35. Structure image for Boc-D-Arg(Tos)-PAM Resin
    Boc-D-Arg(Tos)-PAM Resin

    Product code: PAM5705

    Particle size : 100-200 mesh

  36. Structure image for Boc-D-Asn-PAM Resin
    Boc-D-Asn-PAM Resin

    Product code: PAM5710

    Particle size : 100-200 mesh

  37. Structure image for Boc-D-Asp(Bzl)-PAM Resin
    Boc-D-Asp(Bzl)-PAM Resin

    Product code: PAM5715

    Particle size : 100-200 mesh

  38. Structure image for Boc-D-Cys(4-MeBzl)-PAM Resin
    Boc-D-Cys(4-MeBzl)-PAM Resin

    Product code: PAM5720

    Particle size : 100-200 mesh

  39. Structure image for Boc-D-Gln-PAM Resin
    Boc-D-Gln-PAM Resin

    Product code: PAM5725

    Particle size : 100-200 mesh

  40. Structure image for Boc-D-Glu(Bzl)-PAM Resin
    Boc-D-Glu(Bzl)-PAM Resin

    Product code: PAM5730

    Particle size : 100-200 mesh

  41. Structure image for Boc-D-Leu-PAM Resin
    Boc-D-Leu-PAM Resin

    Product code: PAM5745

    Particle size : 100-200 mesh

  42. Structure image for Boc-D-Lys(2-Cl-Z)-PAM Resin
    Boc-D-Lys(2-Cl-Z)-PAM Resin

    Product code: PAM5750

    Particle size : 100-200 mesh

  43. Structure image for Boc-D-Met-PAM Resin
    Boc-D-Met-PAM Resin

    Product code: PAM5755

    Particle size : 100-200 mesh

  44. Structure image for Boc-D-Phe-PAM Resin
    Boc-D-Phe-PAM Resin

    Product code: PAM5760

    Particle size : 100-200 mesh

  45. Structure image for Boc-D-Pro-PAM Resin
    Boc-D-Pro-PAM Resin

    Product code: PAM5765

    Particle size : 100-200 mesh

  46. Structure image for Boc-D-Ser(Bzl)-PAM Resin
    Boc-D-Ser(Bzl)-PAM Resin

    Product code: PAM5770

    Particle size : 100-200 mesh

  47. Structure image for Boc-D-Thr(Bzl)-PAM Resin
    Boc-D-Thr(Bzl)-PAM Resin

    Product code: PAM5775

    Particle size : 100-200 mesh

  48. Structure image for Boc-D-Trp-PAM Resin
    Boc-D-Trp-PAM Resin

    Product code: PAM5780

    Particle size : 100-200 mesh

  49. Structure image for Boc-D-Tyr(2-Br-Z)-PAM Resin
    Boc-D-Tyr(2-Br-Z)-PAM Resin

    Product code: PAM5786

    Particle size : 100-200 mesh

  50. Structure image for Boc-D-Val-PAM Resin
    Boc-D-Val-PAM Resin

    Product code: PAM5790

    Particle size : 100-200 mesh