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Monofunctionalized dextrans carrying a single functional group on the end of the polymer. These monofunctionalized dextrans can be used much like PEG-it can be used to increase protein half-life, reduce immunogenicity, and passivate surfaces.
The dextran main chain is alpha-1,6-glucose with about 5% alpha-1,3-branching.
Drug delivery with a pH-sensitive star-like dextran-graft polyacrylamide copolymer; A. Grebinyk, S. Prylutska, S. Grebinyk, S. Ponomarenko, P. Virych, V. Chumachenko, N. Kutsevol, Y. Prylutskyy, U. Ritter, M. Frohme; Nanoscale Adv. 2022; 4: 507-5088. https://doi.org/10.1039/D2NA00353H
Dextran conjugates in drug delivery; J. Varshosaz; Expert Opinion on Drug Delivery 2012; 9(5): 509-523. https://doi.org/10.1517/17425247.2012.673580
Chapter 12 - Dextran-based nanomaterials in drug delivery applications; S. Maity, S. Saha, S. Sarkar, P. Kumar, A. Kumar Gautam, A. Bharti Sonkar; Biopolymer-Based Nanomaterials in Drug Delivery and Biomedical Applications 2021; 293-312. https://doi.org/10.1016/B978-0-12-820874-8.00019-1
Recent advances in dextran-based drug delivery systems: From fabrication strategies to applications; Q. Hu, Y. Lu, Y. Luo; Carbohydrate Polymers 2021; 264: 117999. https://doi.org/10.1016/j.carbpol.2021.117999
Preparation and drug delivery of dextran-drug complex; S. Huang, G. Huang; Drug Deliv. 2019; 26(1): 252-261. https://doi.org/10.1080/10717544.2019.1580322
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