Publication

  1. Novel Disulfide Bond Formation Strategies in Solid-Phase Peptide Synthesis

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  2. Eco-Friendly Combination of the Immobilized PGA Enzyme and the S-Phacm Protecting Group for the Synthesis of Cys-Containing Peptides

    Enzyme‐labile protecting groups have emerged as a green alternative to conventional protecting groups.

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  3. A Total New Game for the Synthesis of Disulfide-Containing Peptides

    The overall goal of our research is to capitalize on peptides of natural origin and their biological activity and chemistry.

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  4. N-Fmoc-a-sulfo-b-alanine: a versatile building block for the water solubilisation of chromophores and fluorophores by solid-phase strategy

    Abstract: An easy and efficient solid-phase synthesis strategy to obtain rapidly water-soluble chromophores/fluorophores in highly pure form has been developed.

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  5. Parallel Synthesis and Reaction Optimization

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  6. The concept of internal solubilization in peptide synthesis: ethylene glycol-based protecting groups

    A novel, ethylene glycol-based protecting group is designed and synthesized for use in solid phase peptide synthesis.

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  7. Shorter Arginine homologues to stabilize peptides towards tryptic digestion

    Abstract: Trypsin digests peptides at the position of arginine. Because shorter homologues of arginine with appropriate protecting groups for conventional Fmoc/tBu peptide synthesis are now available, three model peptides containing arginine and two shorter homologues of arginine were synthesized.

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  8. PEGylation - The Magic Wand IRIS Biotech GmbH - Turning Proteins and other Biopharmaceuticals into Super Performing Block Busters

    Abstract: In 2006 the market of modern biopharmaceuticals has reached a volume of over 3 billion in USA and over billion world wide (IMS Health, Inc.).

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  9. From Production of Peptides in Milligram Amounts for Research to Multi-Tons Quantities for Drugs of the Future

    Peptides are key to modern drug discovery. This article reviews the requirements for bulk production of peptides and how it affects research and production of smaller scales.

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  10. Resin-bound mercapto acids: synthesis and application.

    Mercapto acids were attached through their thiol group onto 2-chlorotrityl (Clt)-, trityl (Trt)-, 4-methyltrityl (Mtt)-, 4-methoxytrityl (Mmt)-, and 4,4'-dimethoxytrityl (Dmt)-resins.

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