Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Thank you very much for your interest in our products. All prices listed on our website are ex-works, Germany, and may attract customs duties when imported.
You may/will be contacted by the shipping company for additional documentation that may be required by the US Customs for clearance.
We offer you the convenience of buying though a local partner, Peptide Solutions LLC who can import the shipment as well as prepay the customs duties and brokerage on your behalf and provide the convenience of a domestic sale.Continue to Iris Biotech GmbHSend request to US distributor
Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-3-chloro-L-alanine // Synonyms: (R)-2-[(9-Fluorenylmethyloxycarbonyl)amino]-3-chloro-propionic acid, Fmoc-beta-chloro-L-alanine, Fmoc-3-chloro-L-alanine, Fmoc-Ala(3-Cl)-OH
Starting at $195.00
The Chlorine function in this building block is labile and reactive. Depending on reaction conditions, it is prone to nucleophilic substitution or to elimination. Thus, it is not primarily a building block to permanently introduce 3-Chloroalanine into a peptide, but rather to use the function for further modification such as cyclic peptide ring closure or introduction of Dehydroalanine. However, there are also publications (see below) reporting introduction of 3-Chloroalanine into peptides without elimination.
Halogen Bonding: A Powerful Tool for Modulation of Peptide Conformation; E. Danelius, H. Andersson, P. Jarvoll, K. Lood, J. Gräfenstein, M. Erdélyi; Biochemistry 2017; 56: 3265-3272. https://doi.org/10.1021/acs.biochem.7b00429
Cyclization of Peptides by using Selenolanthionine Bridges; A. D. de Araujo, M. Mobli, G. F. King, P. F. Alewood; Angew. Chem. Int. Ed. 2012; 51: 10298-10302. https://doi.org/10.1002/anie.201204229
Do you need larger quantities for your development or production?
Please send me more information about