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Fmoc-L-2Aod-OH
Chemical name: (S)-N-(9-Fluorenylmethyloxycarbonyl)-L-2-aminooctadec-9-enoic acid // Synonyms: (S,Z)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)octadec-9-enoic acid, Fmoc-L-2-aminooctadec-9-enoic acid, Fmoc-L-2-amino-(9Z)-oleic acid, Fmoc-L-2-aminooctadec-9-enoic acid,Fmoc-2Aod-OH
- Product code:FAA8545
- Formula:C33H45NO4
- Molecular weight:519.73 g/mol
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description
Fatty amino acids improve the pharmacokinetic & pharmacologic properties of peptide APIs and other biopharmaceuticals. The most prominent block busters are Liraglutide and Semaglutide. Their lifetime in serum is drastically improved as the fatty acid residue helps to bind temporarily to serum albumin. This conjugation enhances stability towards proteolytic degradation and serves as drug delivery technique.
references
Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide; J. Lau, P. Bloch, L. Schäffer, I. pettersson, J. Spetzler, J. Kofoed, K. Madsen, L. B. Knudsen, J. McGuire, D. B. Steensgaard, H. M. Strauss, D. X. Gram, S. M. Knudsen, F. S. Nielsen, P. Thygesen, S. Reedtz-Runge, T. Kruse; J. Med. Chem. 2015; 58(18): 7370-7378. https://doi.org/10.1021/acs.jmedchem.5b00726.
Peptide Half-Life Extension: Divalent, Small-Molecule Albumin Interactions Direct the Systemic Properties of Glucagon-Like Peptide 1 (GLP-1) Analogues; E. M. Bech, M. C. Martos-Maldonado, P. Wismann, K. K. Sørensen, S. Blok van Witteloostuijm, M. B. Thygesen, N. Vrang, J. Jelsing, S. L. Pedersen, K. J. Jensen; J. Med. Chem. 2017; 60(17): 7434-7446. https://doi.org/10.1021/acs.jmedchem.7b00787.
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