N3-L-Cit-OH*DCHA

Chemical name: (S)-2-Azido-citrulline dicyclohexylamine // Synonyms: N3-Cit*DCHA, N3-L-Cit-OH dicyclohexylamine salt, N3-Cit-OH, azido-citrulline dicyclohexylammonium salt, N‐cyclohexylcyclohexanaminium (2S)‐2‐azido‐5‐(carbamoylamino)pentanoate

Art-No.:HAA4980
Cas-no.:1799421-66-1 net
Formula:C6H11N5O3*C12H23N
Molecular weight:201,18*181,32 g/mol
Grouped product items
Product variant
500 mg
$121.50
HAA4980.0500
1 g
$189.00
HAA4980.0001
5 g
$675.00
HAA4980.0005
25 g
$2,700.00
HAA4980.0025
description
Used by Genentech to construct novel peptidomimetic ADC linkers using Click-chemistry.

references
Discovery of Peptidomimetic AntibodyDrug Conjugate Linkers with Enhanced Protease Specificity. BinQing Wei, Janet Gunzner-Toste, Hui Yao, Tao Wang, Jing Wang, Zijin Xu, Jinhua Chen, John Wai, Jim Nonomiya, Siao Ping Tsai, Josefa Chuh, Katherine R. Kozak, Yichin Liu, Shang-Fan Yu, Jeff Lau, Guangmin Li, Gail D. Phillips, Doug Leipold, Amrita Kamath, Dian Su, Keyang Xu, Charles Eigenbrot, Stefan Steinbacher, Rachana Ohri, Helga Raab, Leanna R. Staben, Guiling Zhao, John A. Flygare, Thomas H. Pillow, Vishal Verma, Luke A. Masterson, Philip W. Howard, Brian Safina; J. Med. Chem. 2018; 61(3): 989-1000. DOI: 10.1021/acs.jmedchem.7b01430.

Peptidomimetic compounds and antibody-drug conjugates thereof. John Flygare, Janet Gunzner-Toste, Thomas Pillow, Brian Safina, Vishal Verma, Binqing Wei, Guiling Zhao, Leanna Staben, Philip Wilson Howard, Luke Masterson; PCT Int. Appl. 2015; WO 2015095124 A1.

Peptidomimetic compounds and antibody-drug conjugates thereof. Ho Huat Lee, Moana Tercel, John A. Flygare, Janet Gunzner-Toste, Thomas H. Pillow, Brian Safina, Leanna Staben, Vishal Verma, Binqing Wei, Guiling Zhao; PCT Int. Appl. 2015; WO 2015095227 A2.

Peptidomimetic compounds and antibody-drug conjugates thereof. John Flygare, Janet Gunzner-Toste, Thomas Pillow, Brian Safina, Vishal Verma, Binqing Wei, Guiling Zhao, Leanna Staben; PCT Int. Appl. 2015; WO 2015095223 A2.

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