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Gly-CBT*HCl
Chemical name: 2-Amino-N-(2-cyano-6-benzothiazolyl)acetamide hydrochloride // Synonyms: CBT-Glycine, CBTG, Glycine-cyanobenzothiazole, Cyanobenzothiazolyl-glycine, 2-Amino-N-(2-cyanobenzo[D]thiazol-6-yl) acetamide, 2-amino-N-(2-cyano-1,3-benzothiazol-6-yl) acetamide,CBT-Gly
- Product code:RL-4220
- CAS No.:1207457-28-0 net
- Formula:C10H8N4OS*HCl
- Molecular weight:232.26*36.45 g/mol
Starting at $375.00
description
The site-specific labeling of proteins by chemical reactions has gained increased interest for the investigation of cellular processes. In this regard, the CBT-Cys „click“ condensation reaction has found wide applicability in recent years. The reaction is highly biocompatible and controllable and runs under physiological conditions. It is based on the condensation between an N-terminal L- or D-Cysteine with the cyano group of CBT.
references
A Biocompatible Condensation Reaction for the Labeling of Terminal Cysteine Residues on Proteins; H. Ren, F. Xiao, K. Zhen, Y.P. Kim, H. Xie, Z. Xia, J. Rao; Angew. Chem. Int. Ed. 2009, 48: 9658-9662. https://doi.org/10.1002/anie.200903627
Genetically Encoded 1,2-Aminothiols Facilitate Rapid and Site-Specific Protein Labeling via a Bio-orthogonal Cyanobenzothiazole Condensation; J. Am. Chem. Soc. 2011, 133(30): 11418–11421. https://doi.org/10.1021/ja203111c
Site-specific immobilization of biomolecules by a biocompatible reaction between terminal cysteine and 2-cyanobenzothiazole; P. Wang, C.J. Zhang, G. Chen, Z. Na, S. Q. Yao, H. Sun; Chem. Commun. 2013, 49: 8644-8646. https://doi.org/10.1039/C3CC43566K
Sequence-Specific 2-Cyanobenzothiazole Ligation; C. P. Ramil, P. An, Z. Yu, Q. Lin; J. Am. Chem. Soc. 2016, 138 (17): 5499–5502. https://doi.org/10.1021/jacs.6b00982
Peptide cleavage induced assembly enables highly sensitive electrochemiluminescence detection of protease activity; M. Cheng, J. Zhuo, X. Zhou, D. Xing; Sens. Actuators B Chem. 2018, 262: 516-52. https://doi.org/10.1016/j.snb.2018.01.191
Injectable hyaluronic acid hydrogels encapsulating drug nanocrystals for long-term treatment of inflammatory arthritis; Y. Gao, D. Vogus, Z. Zhao, W. He, V. Krishnan, J. Kim, Y. Shi, A. Sarode, A. Ukidve, S. Mitragotri; Bioeng. Transl. Med. 2022, 7: e10245. https://doi.org/10.1002/btm2.10245
Affinity Bioorthogonal Chemistry (ABC) Tags for Site-Selective Conjugation, On-Resin Protein-Protein Coupling, and Purification of Protein Conjugates; S. L. Scinto, T. R. Reagle, J. M. Fox; Angew. Chem. Int. Ed. 2022, 61: e202207661. https://doi.org/10.1002/anie.202207661
Optimized molecular design of PET probe for the visualization of γ-glutamyltranspeptidase activity in tumors; X. Wang, D. Gao, C. Lu, M. Xie, J. Lin, L. Qiu; New J. Chem. 2022, 46: 10219-10228. https://doi.org/10.1039/D2NJ01688E
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