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Christmas Donation from 2019

Noncanonical amino acids: Tools for biological and biophysical investigations

21 - 22 October 2019

Product of the Month: Fmoc-L-Cys(Allocam)-OH for 1-Step On-Resin Disulfide Bond Formation

The Allocam protecting group allows for selective deprotection and disulfide bond formation on-resin in one step.

Diazirine Amino Acids: Photocrosslinking Applications

Two selected publications were summarized in this article in order to highlight the impressive utility of amino acids incorporating the diazirine photophore.

Protease Inhibitors

Protease inhibitors are molecules that inhibit protease function by binding either reversibly or irreversibly to the enzyme.

Membrane-Impermeant Biotin Tyramide

Methods for proteomic mapping of cellular organelles or subdomains that avoid the necessity of cell lysis and purification by targeting specific subcellular regions have several advantages.

Fmoc-L-Lys(Nvoc)-OH

o-Nitroveratryloxycarbonyl (Nvoc) is a photocleavable side chain protecting group for lysine that can be removed by irradiation with UV light (350 nm).

H-L-Lys(Suc)-OH*HCl

Succinylation of proteins on the epsilon-amino group of lysine residues is a posttranslational modification that is still poorly understood.

Amadori & Maillard reaction derived peptides

Find below derivatives of arginine and lysine bearing side chains as found in Maillard reaction products.

(TPP-Lys(TPP))2-Lys-Gly-Gly-Gly-N2H3*4Br*TFA

Delivery of hydrophilic compounds across membranes is usually problematic. Modification with triphenylphosphonium ions has been shown to overcome this barrier.