1. Thiol-reactive Linkers for ADCs

    The thiosuccinimide linkage is a prominent connective motif resulting from the reaction of a thiol and an alkyl maleimide. Read on to learn more about its applications and potential improvements.

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  2. Valine-Citrulline Based Enzymatically Cleavable Linkers

    Iris Biotech presents its selection of Val-Cit-based linkers, a dipeptide motif frequently utilized for the development of ADCs with increased serum stability and high cleavage efficiency.

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  3. His-Tag for Specific Linker Attachment

    Learn, how His-Tag can be used for specific linker attachment. Another example in our LINKEROLOGY series of sophisticated linker technologies.

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  4. Product of the Month: Dde-based Linkers

    Placing Dde as one terminal group of a linker and a functional group prone for conjugation as the other or using Dde as the central connective portion of a linker, allows for the creation of new bifunctional linkers.

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  5. Subject Focus: Linkerology

    The ever-growing sophistication and variation in linker design have given rise to a new and distinct field of knowledge in synthetic chemistry termed Linkerology. Discover our expertise and panoply of new cutting-edge tailor-made linker constructs for the latest state-of-the-art bioconjugations.

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  6. Cleavable Bifunctional Biotin-Linkers

    Biotinylation of proteins and their purification via Streptavidin beads is a widely applied method.

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  7. The Safety-Catch Acid-Labile (SCAL)-Linker

    The SCAL linker offers superior chemical stability and permits a variety of orthogonal solid-phase approaches. It is fully compatible with the Fmoc-, Boc- and Alloc- strategies. Cleavage can be performed either by a simultaneous, or by a two-step reduction/acidolysis procedure to afford peptide amides.

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  8. 3rd Generation Click Chemistry: Tetrazine and TCO Derivatives for Copper-free Conjugation

    The reaction between a tetrazine (Tz) and a trans-cyclooctene (TCO) is the innovative third generation Click reaction that proceeds without the use of copper or other catalyst. It is rapid, fully bioorthogonal and excels at very low concentrations.

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  9. Photo-Linker for Peptide Amides and Acids

    Peptide linkers usually are cleaved under acidic conditions or using two-step procedures. Photocleavage proceeds under neutral conditions using UV light and can either be performed in batch or using flow chemistry.

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  10. Linkers for Antibody-Drug Conjugation (ADC)

    Cleavable dipeptide linkers like Val-Ala and Val-Cit rely on processes inside the cell to liberate the payload, as they undergo rapid hydrolysis in the presence of lysosomal extracts or purified human cathepsin B.

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