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N3-PEG(3)-SQA

Chemical name: 3-((2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)amino)-4-ethoxycyclobut-3-ene-1,2-dione // Synonyms: N3-PEG3-NH-SQ-OEt, Azido-PEG3-Ethylsquaramide, SQ-PEG3-N3, N3-PEG3-Squarate

  • Product code:RL-4420
  • CAS No.:2920089-51-4
  • Formula:C14H22N4O6
  • Molecular weight:342.35 g/mol
  • Purity :min. 98,0%

Starting at $112.50

Grouped product items
Qty Packing unit Price SKU
250 mg
$112.50
RL-4420.0250
500 mg
$202.50
RL-4420.0500
1 g
$315.00
RL-4420.1000
5 g
$1,125.00
RL-4420.5000
25 g
$4,500.00
RL-4420.9025
description

A clickable PEG linker that can be reacted with amines and other nucleophiles.

This monoester amide has a high hydrolytic stability at alkaline pH making it superior bioconjugation tool when compared to conventional activated esters.

references

RAFT Polymer–Antibody Conjugation: Squaramide Ester Chemistry Leads to Conjugates with a Therapeutic Anti-EGFR Antibody with Full Retention of Activity and Increased Tumor Uptake In Vivo; A. Ardana, S. Ghosh, P. Huda, N. L. Fletcher, K. J. Thurecht, C. C. Williams; Mol. Pharmaceutics 2023; 20(6): 3073–3087. https://doi.org/10.1021/acs.molpharmaceut.3c00085

WO2023049963A1

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