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Fmoc-cis-Apc
Chemical name: cis-1-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-phenylcyclohexanecarboxylic acid // Synonyms: Fmoc-cis-Ac6c(4-Ph)-OH, (1s,4s)-1-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-phenylcyclohexane-1-carboxylic acid
- Product code:FAA8625
- CAS No.:365550-63-6
- Formula:C28H27NO4
- Molecular weight:441.53 g/mol
Starting at $2,250.00
description
This building block might serve as constrained phenylalanine analogue for structure activity relationship studies.
references
Design of Organo-Peptides As Bipartite PCSK9 Antagonists; D. J. Burdick, N. J. Skelton, M. Ultsch, M. H. Beresini, C. Eigenbrot, W. Li, Y. Zhang, H. Nguyen, M. Kong-Beltran, J. G. Quinn, D. Kirchhofer; ACS Chem. Biol. 2020; 15(2): 425-436. https://doi.org/10.1021/acschembio.9b00899.
Discovery of 1-amino-4-phenylcyclohexane-1-carboxylic acid and its influence of agonist selectivity between human melanocortin-4 and -1 receptors in linear pentapeptides; X.-J. Chu, D. Bartkovitz, W. Danho, J. Swistok, A. Wai-Hing Cheung, G. Kurylko, K. Rowan, M. Yeon, L. Franco, L. Yi, L. Chen, K. Yagaloff; Bioorg. Med. Chem. Lett. 2005; 15(22): 4910-4914. https://doi.org/10.1016/j.bmcl.2005.08.012.
Preparation of human Melanocortin-4 receptor agonist libraries: Linar peptides X-Y-DPhe7-Arg8-Trp(or 2-Nal)9-Z-NH2; A. Wai-Hing Cheung, L. Qi, V. Gore, X.-J. Chu, D. Bartkovitz, G. Kurylko, J. Swistok, W. Danho, L. Chen,
K. Yagaloff; Bioorg. Med. Chem. Lett. 2005; 15(24): 5504-5508. https://doi.org/10.1016/j.bmcl.2005.08.083.
A predictive pharmacophore model of human melanocortin-4 receptor as derived from the solution structures of cyclic peptides; H. Sun, D. N. Greeley, X.-J. Chu, A. Cheung, W. Danho, J. Swistok, Y. Wang, C. Zhao, L. Chen, D. C. Fry; Bioorg. Med. Chem. 2004; 12(10): 2671-2677. https://doi.org/10.1016/j.bmc.2004.03.017.
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