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Fmoc-L-Lys(oNB)-OH
Chemical name: N2-(((9H-fluoren-9-yl)methoxy)carbonyl)-N6-(((2-nitrobenzyl)oxy)carbonyl)-L-lysine // Synonyms: Fmoc-ONBK, Fmoc-L-Lys(2-NO2-Z), Fmoc-L-Lys(2-nitrobenzyloxycarbonyl), N-epsilon-(o-nitrobenzyl-oxycarbonyl)-Fmoc-L-lysine, N-epsilon-(o-nitrobenzyloxycarbonyl)-Fmoc-L-lysine,Fmoc-Lys(oNZ)
- Product code:FAA9365
- CAS No.:228564-77-0
- Formula:C29H29N3O8
- Molecular weight:547.56 g/mol
- Purity :min. 98.0%
Starting at $270.00
description
Photocaged Lysine derivative suitable for SPPS that can be incorporated into peptides. The photolabile group can be efficiently removed by 365 nm light to afford a free lysine residue.
references
External-Radiation-Induced Local Hydroxylation Enables Remote Release of Functional Molecules in Tumors; Q. Fu, H. Li, D. Diam. C. Wang, S. Shen, H. Ma, Z. Liu; Angew. Chem. Int. Ed. 2020; 59(48): 21546-21552. https://doi.org/10.1002/anie.202005612
Synthesis of caged peptides using caged lysine: Application to the synthesis of caged AIP, a highly specific inhibitor of calmodulin-dependent protein kinase II; Y. Tatsu, Y. Shigeri, A. Ishida, I. Kameshita, H. Fujisawa; N. Yumoto; Bioorg. Med. Chem. Lett. 1999; 9(8): 1093-1096. https://doi.org/10.1016/S0960-894X(99)00140-7
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