N3-PEG-SQA (3 kDa)

Chemical name: alpha-Azido-omega-squaric acid ethyl ester poly(ethylene glycol) (PEG-MW 3000 Dalton) // Synonyms: N3-PEG(3 kDa)-SQA

Product code:PEG6655
Molecular weight:3000 Da
Grouped product items
Qty Packing unit Price SKU
500 mg
$749.25
PEG6655.0500
1 g
$1,343.25
PEG6655.0001
description

PEGylating reagent with squaric acid ethyl ester, which reacts chemoselectively with amino functions of lysine in proteins. Guanidine functions of arginines, hydroxy groups of serine and threonine and imidazoles from histidines are not affected.

references

Squaric Acid Mediated Chemoselective PEGylation of Proteins: Reactivity of Single-Step-Activated a-Amino Poly(ethylene glycol)s; Carsten Dingels, Frederik Wurm, Manfred Wagner,

Harm-Anton Klok, Holger Frey;

Chem. Eur. J. 2012; 18(52): 16828-16835. DOI: 10.1002/chem.201200182.

Synthetic Vaccines Consisting of Tumor-Associated MUC1 Glycopeptide Antigens and a T-Cell Epitope for the Induction of a Highly Specific Humoral Immune Response; Ulrika

Westerlind, Alexandra Hobel, Nikola Gaidzik, Edgar Schmitt, Horst Kunz; Angew Chem Int Ed 2008; 47: 7551-7556. DOI: 10.1002/anie.200802102.

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